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The oligonucleotide synthesis market size is estimated to grow at a CAGR of 13.47% between 2022 and 2027. The market size is forecast to increase by USD 2,870.69 million. The growth of the market depends on several factors, including the increasing research activities in the pharmaceutical and biotechnology sectors, and increasing use of oligonucleotides as therapeutic and diagnostic tools, and the emergence of technological innovations in oligonucleotide synthesis. Challenges such as regulatory issues associated with oligonucleotide therapeutics, diversity in oligonucleotide molecules, and challenges in effective oligonucleotide delivery might restrain the growth of the market. Nevertheless, factors such as increasing focus on R and D of new oligonucleotide therapeutics, increasing research funding, and rise in demand for low-cost and high-throughput oligonucleotide synthesis is key trend shaping the market.
This oligonucleotide synthesis market report extensively covers market segmentation by application (PCR primers, fluorescence in situ hybridization, PCR assays and panels, DNA microarrays, and others), end-user (pharmaceutical and biotechnology companies, research and academic institutes, diagnostic laboratories, and hospitals), and geography (North America, Europe, Asia, and Rest of World (ROW)). It also includes an in-depth analysis of drivers, trends, and challenges. Furthermore, the report includes historic market data from 2017 to 2021.
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Our researchers analyzed the data with 2022 as the base year, along with the key drivers, trends, and challenges. A holistic analysis of drivers will help companies refine their marketing strategies to gain a competitive advantage.
The increasing research activities in the pharmaceutical and biotechnology sectors are notably driving the market growth. The increasing prevalence of chronic and life-threatening diseases is propelling the demand for pharmaceutical and biotechnological research on the development of effective therapeutics and diagnostic techniques. Advances in life sciences research have resulted in an improved understanding of biological systems. This has led to an increase in life science research using genetic engineering technologies.
The development of oligonucleotide synthesis technologies has helped pharmaceutical and biotechnology researchers with molecular-level development, design, and modification of biological systems. Recombinant protein production has been used as a tool to analyze the Functional and Structural Analysis of several Biologicals, such as therapeutic monoclonal antibodies and target proteins. Oligonucleotide synthesis is the initial step for the expression of recombinant protein and contributes to recombinant protein diversity that helps in further research and development of therapeutics.
Oligonucleotides as primers have revolutionized the research in disease processes and gene expression through antisense oligonucleotide technology. In order to limit protein synthesis by inhibiting translation, pharmaceutical, and biotechnology researchers are consistently focusing on the use of antisense oligonucleotides. This approach has also contributed to the development of a number of treatments, including antisense oligonucleotides for familial hypercholesterolemia and cytomegalovirus retinitis. Such factors are expected to drive the growth of the global oligonucleotide synthesis market during the forecast period.
The rise in demand for low-cost and high-throughput oligonucleotide synthesis is a primary trend in the oligonucleotide synthesis market. The large-scale production of desired gene sequences at a lower cost could contribute to rapid progress in both fundamental and applied biological research. The costs of gene synthesis are directly proportional to the cost of oligonucleotide synthesis since genetic material is made from oligonucleotides. The reduction of the oligonucleotide synthesis costs makes it possible to generate a more efficient set of gene data. Hence, there is an increasing demand for techniques and technologies that allow the synthesis of oligonucleotides and their assembly into larger DNA constructs with increased sequence fidelity at a reduced cost.
Automated methods have become more common, such as the synthesis of oligonucleotides with Computer Controlled Instruments for Solid Phase Support. The major costs of gene synthesis are also associated with reagents that are applied for oligonucleotide synthesis. Hence, there is an increasing demand for approaches and tools that reduce reagent consumption, enhance the robustness and accuracy of the gene assembly process, and increase throughput in oligonucleotide synthesis. Such factors are expected to drive the growth of the global oligonucleotide synthesis market during the forecast period.
The diversity in oligonucleotide molecules is a major challenge in oligonucleotide synthesis. Oligonucleotides are larger molecules than traditional small molecules used in therapeutics. Effective uptake of oligonucleotides in a targeted location decides the success of drug candidates. However, the diversity within the classes of therapeutics in terms of the size of the molecule and range of chemical modification necessitates careful consideration before nucleic acid synthesis.
Furthermore, as compared to complex molecules, the availability of fewer target sites allows small molecules to be modified in a restricted manner. For this reason, in order to address the different mechanisms of action and features of these molecules, it is important that all oligonucleotide types are considered carefully. The complexity and diversity in oligonucleotide molecules increase the propensity for performance failure of drug candidates due to undetected impurity and toxicity. Thus, non-compliance with regulatory requirements can negatively impact drug manufacturers. This trend is expected to hinder the growth of the global oligonucleotide synthesis market over the forecast period.
The market report includes the adoption lifecycle of the market, covering from the innovator’s stage to the laggard’s stage. It focuses on adoption rates in different regions based on penetration. Furthermore, the report also includes key purchase criteria and drivers of price sensitivity to help companies evaluate and develop their growth strategies.
Global Oligonucleotide Synthesis Market Customer Landscape
Vendors are implementing various strategies, such as strategic alliances, partnerships, mergers and acquisitions, geographical expansion, and product/service launches, to enhance their presence in the market.
Agilent Technologies Inc. - The company offers oligonucleotide synthesis products such as SurePrint HiFi.
The research report also includes detailed analyses of the competitive landscape of the market and information about 15 market vendors, including:
Qualitative and quantitative analysis of vendors has been conducted to help clients understand the wider business environment as well as the strengths and weaknesses of key market players. Data is qualitatively analyzed to categorize vendors as pure play, category-focused, industry-focused, and diversified; it is quantitatively analyzed to categorize vendors as dominant, leading, strong, tentative, and weak.
The market share growth by the PCR Primers segment will be significant during the forecast period. PCR primers are short oligonucleotide sequences that are designed to bind to specific target DNA sequences and initiate the amplification process in PCR reactions. They serve as essential components in PCR-based applications, including gene expression analysis, DNA sequencing, mutation detection, and genotyping.
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The PCR Primers segment shows a gradual increase in the market share of USD 512.13 million in 2017 and continue to grow by 2021. The demand for PCR primers is particularly high in high-throughput applications, such as large-scale genotyping or DNA sequencing projects. Oligonucleotide synthesis companies are equipped to handle the synthesis of a large number of PCR primers simultaneously to support these high-throughput applications. The growth of the PCR primers segment in the Global oligonucleotide Synthesis Market is projected to benefit from these factors over the forecast period.
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North America is estimated to contribute 43% to the growth of the global market during the forecast period. Technavio’s analysts have elaborately explained the regional trends and drivers that shape the market during the forecast period.
North America dominates the regional l oligonucleotide synthesis market, with the US leading the regional market. The adoption of synthetic nucleic acids for research, therapeutic applications, and diagnosis is driven by the presence of a leading market. Vendors in the US are using advanced technologies and methodologies to meet the growing demand for oligonucleotides.
The COVID-19 outbreak led to a slight decline in the growth of the oligonucleotide synthesis market in North America in 2020. However, the adoption of telehealth and the lifting of stay-at-home policies regained market revenue in the region. In 2021 the resumption of business activities, including research programs for oligonucleotide synthesis therapeutics, resulted in returning to normalcy as a result of vaccination campaigns carried out by national governments and relaxed security measures. These factors are predicted to have a positive effect on the regional oligonucleotide synthesis market over the forecast period.
The oligonucleotide synthesis market report forecasts market growth by revenue at global, regional & country levels and provides an analysis of the latest trends and growth opportunities from 2017 to 2027.
Technavio categorizes the Oligonucleotide Synthesis Market as a part of the global life science tools and services market. The parent, global life science tools and services market covers products and companies engaged in R & D of a variety of product categories, including capital equipment, instruments, accessories, and consumables that are used for R&D on pharmaceuticals and biotechnology products and laboratory diagnosis of various diseases. It shall also cover services in the area of life sciences related to research, contract production, and sales. Our market research report has extensively covered external factors influencing the parent market growth during the forecast period.
Oligonucleotide Synthesis Market Scope |
|
Report Coverage |
Details |
Page number |
178 |
Base year |
2022 |
Historic period |
2017-2021 |
Forecast period |
2023-2027 |
Growth momentum & CAGR |
Accelerate at a CAGR of 13.47% |
Market growth 2023-2027 |
USD 2870.69 million |
Market structure |
Fragmented |
YoY growth 2022-2023(%) |
13.31 |
Regional analysis |
North America, Europe, Asia, and Rest of the World (ROW) |
Performing market contribution |
North America at 43% |
Key countries |
US, Canada, Germany, China, and Japan |
Competitive landscape |
Leading Vendors, Market Positioning of Vendors, Competitive Strategies, and Industry Risks |
Key companies profiled |
Agilent Technologies Inc., Ajinomoto Co. Inc., Alnylam Pharmaceuticals Inc., Bio Synthesis Inc, Biocon Ltd., Biotage AB, Danaher Corp., Eurofins Scientific SE, General Electric Co., Ionis Pharmaceuticals Inc., Kaneka Corp., LGC Science Group Holdings Ltd., Maravai LifeSciences Holdings Inc., Merck KGaA, Mettler Toledo International Inc., QIAGEN NV, Sarepta Therapeutics Inc, Synbio Technologies, Thermo Fisher Scientific Inc., and Biogen Inc. |
Market dynamics |
Parent market analysis, Market growth inducers and obstacles, Fast-growing and slow-growing segment analysis, COVID-19 impact and recovery analysis and future consumer dynamics, and Market condition analysis for the forecast period. |
Customization purview |
If our report has not included the data that you are looking for, you can reach out to our analysts and get segments customized. |
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