Amniotic Membrane Market by End-user, Type, and Geography - Forecast and Analysis 2023-2027

Amniotic Membrane Market 2023-2027

The global amniotic membrane market size is estimated to grow by USD 2.3 billion, at a CAGR of 14.6% between 2022 and 2027. 

Amniotic membranes are extensively used in wound repair and reconstruction therapies. They're a protective cover that lies over the wound, which is used to provide essential components. In addition, antimicrobial membrane reduces the formation of scars, monomeric inflammation, and pain as well as reducing the occurrence of microbial infection in wounds. The membrane has been preferred in the treatment of serious ulcers, among repair and reconstruction applications. The increasing prevalence of chronic ulcers is giving a boost to the demand for advanced wound care treatment procedures, thereby driving the growth of the market globally. An adequate supply of wound healing components and growth factors that help accelerate the repair of diabetes foot ulcers are offered by the market. Such benefits have increased the adoption of amniotic membranes in wound care management procedures.

What will be the size of the Market During the Forecast Period?

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Market Segmentation 

This report extensively covers market segmentation by end-user (hospitals, ambulatory surgical centers, specialty clinics, and research and academic institutes), type (cryopreserved amniotic membrane and dehydrated amniotic membrane) and geography (North America, Europe, Asia, and Rest of World (ROW)).

Market Dynamics and Customer Landscape

The market is driven by the growing demand for regenerative medicine and tissue-based products in various medical applications. With advancements in healthcare systems and the medical device industry, there's increasing recognition of the therapeutic benefits of amniotic membrane treatments for conditions like ocular diseases, burn injuries, and surgical wounds. However, challenges persist, including regulatory compliance, market fragmentation, and technological limitations. Despite these hurdles, the market shows promising trends towards the development of innovative treatments and the expansion of its applications in addressing traumatic wounds and non-healing chronic wounds, supported by its anti-inflammatory and antibacterial properties. There are multiple factors influencing market growth. Our researchers analyzed the data with 2022 as the base year, along with the key drivers, trends, and challenges. 

Key Market Drivers

The extensive use of amniotic membrane transplantation in ophthalmic surgeries is driving growth in the market. These transplantations have transformed the treatment of ophthalmic conditions, specifically treatments related to ocular surface reconstruction. Due to the characteristics of membranes enabling epithelial cells to migrate, strengthening cell adhesion, and encouraging epithelial diffraction, ocular surface reconstruction procedures have been significantly improved.

Moreover, the market can modulate stromal scarring and have anti-inflammatory properties. Consequently, for the treatment of bullous keratitis, glaucoma or cataract, peripheral limbic stem cell deficiency, persistent epithelium defects, and corneoscleral ulcers, there is a growing trend among ophthalmologists to use amniotic membrane transplantation in cornea surface reconstruction. The increasing number of ophthalmic surgeries is promoting the demand for membranes among end-users such as hospitals and clinics. About 45 million people in the US use contact lenses for vision correction. Such eye infections and disorders increase the demand for ophthalmic reconstruction surgeries across the globe, thereby driving the growth of the market focus during the forecast period. 

Significant Market Trends

The growing reimbursement coverage for new products is a primary trend in the market.  Governments throughout the world are increasingly modifying their reimbursement structure for new health products, to provide value-based care. Tissue-engineered products such as amniotic membranes are considered highly expensive owing to the involvement of a considerable amount of direct and indirect costs in sourcing, storage, transfer, and application.

However, government organizations and market companies are focusing on reimbursing such costs and providing value-based care. This has led to the revision of reimbursement policies for membrane products. Suppliers are making information and guidance available on their websites, with a view to raising awareness of insurance coverage for different products. Such activities are reducing the cost of membranes and increasing awareness regarding coverage policies among patients and medical practitioners, which is expected to drive the growth of the market during the forecast years.

Major Market Challenges

The issues related to preservation and contamination are major challenges in the market. End-users have observed reluctance to adopt the amniotic fluid transfer procedure due to fears of patients transmitting contagious diseases. An amniotic membrane is directly derived from amniotic sacs retrieved during cesarean and vaginal deliveries. Bacterial contaminants are commonly found in vaginal and placental areas that may contaminate the product. In addition, the presence of infectious diseases in a donor can transmit infections to his or her recipient. To avoid these events, companies must carry out serology checks at the time of storage of amniotic membranes.

Additionally, amniotic membranes are required to be stored efficiently before their transplantation. It is a challenging task for market companies and end users to store the membrane while ensuring optimal conditions. Issues that pose challenging sterile storage requirements for market companies and end-users that operate in emerging regions with a lack of advanced storage options. This hampers the revenue growth of companies , thereby declining the growth of the market in focus during the forecast period.

Market Segmentation by End-user, Type and Geography Analysis

The market is witnessing significant growth driven by advancements in regenerative medicine and the increasing adoption of tissue-based products in medical treatments. With a focus on tissue regeneration and the rising prevalence of conditions such as pulmonary fibrosis, ocular diseases, and burn injuries, the demand for amniotic membrane treatments is on the rise. This market caters to various healthcare sectors, offering solutions for surgical wounds, traumatic injuries, and non-healing chronic wounds. The amniotic membrane's anti-inflammatory and antibacterial properties make it a valuable resource in wound care biologics, further enhancing its market potential in addressing diverse medical applications across the globe. 

End-user Analysis

Hospital

The market share growth by the hospital segment will be significant during the forecast period. The market is a versatile biological material derived from the innermost layer of the placenta. Due to the unique characteristics of it, such as its ability to heal wounds with antimicrobial and bacterial activity, it has been applied in a variety of healthcare applications.

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The hospital segment was valued at USD 702.98 million in 2017.  There are a number of different uses for amniotic membranes in hospitals, In the case of eye surgery, it may be used as a graft to enhance wound healing, decrease scar tissue, and repair specific ophthalmological disorders. The amniotic membrane has the potential for gynecological and obstetric applications such as repairing vaginal or cervical lacerations, promoting post-surgical healing, and treating conditions such as intrauterine adhesions. The use of the membranes in hospitals will drive the growth of the market focus during the forecast period.

Type Analysis: 

Cryopreserved amniotic membranes

Cryopreserved amniotic membranes are slow-freezes at -112 degrees Fahrenheit using preservation media such as Dulbeccos modified eagle medium (DMEM) and glycerol, which enables a slower rate of freezing without ice formation. Hesemeric membranes during prolonged storage requirements maintain the integrity of the amniotic membrane, as well as the local ECM architecture. The cryopreservation of key biological signalings proteins, such as the pentraxin 3 complex, fibronectin, collagen, and heavy chain hyaluronic acid present in ECM is helping to maintain their activity and quantity. The increasing coverage of cryopreserved products in reimbursement schemes of governments is promoting the demand for cryopreserved amniotic membranes. The number of tissue banks is also rising owing to the increasing availability of funding. Such a rise in capital funding helps tissue banks to enhance their storage capabilities and use the latest cryopreservation methods for membrane storage, thereby driving the growth of the segment during the forecast period. 

Dehydrated amniotic membranes

Dehydrated amniotic membranes are preserved using a vacuum with low-temperature heat, which helps in retaining the devitalized cellular components. In contrast to cryopreserved membranes, dehydrated amniotic membranes can be stored and preserved at room temperature and, therefore, offer logistic benefits over cryopreserved amniotic membranes. Unlike cryopreserved membranes that are preserved for a period of 5 years, dehydrated membranes extend their shelf life up to 15 years. The dehydrated amniotic membrane in a variety of tissue sizes and thicknesses is being offered by several players on the market, according to medical needs. The low cost and low storage expense advantages over cryopreserved amniotic membranes, backed by the rising adoption of membranes in ophthalmic surgeries, are driving the growth of this segment. The cost of dehydrated membranes is 35% to 40% less compared with the costs of frozen membranes. In addition, at very low temperatures they are not dependent on specialized tissue banks for cryopreservation. Such benefits increase their preference for cryopreserved membranes in various surgical applications, which in turn accelerates the demand for the market

Regional Analysis

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North America is estimated to contribute 56% to the growth of the global market during the forecast period. Technavio’s analysts have explained the regional trends and drivers that will shape the market during the forecast period. North America is the most dominating region in the market, with the US as the leading country. The growth in the North America market is being driven by a growing acceptance of Advanced Wound Care treatments, due to increasing awareness about better healthcare options across people in the USA and Canada as well as increases in demand for orthopaedics. The demand for the market as an advanced treatment for diabetic foot ulcers surged in the country as these products offered value-based and efficient treatment options by providing essential regenerative components to wound areas. This gave a boost to the revenue generated in the market in North America. 

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Key Market Players 

Companies are implementing various strategies, such as strategic alliances, partnerships, mergers and acquisitions, geographical expansion, and product/service launches, to enhance their presence in the market. The report also includes detailed analyses of the competitive landscape of the market and information about 20 market companies, including:

Amnio Technology LLC - The company offers amniotic Membrane products such as chorion-free amniotic membranes.

• Applied Biologics LLC
• BIOHEALING SRO
• Celularity Inc.
• Flower Orthopedics Corp.
• Human Regenerative Technologies LLC
• Integra Lifesciences Corp.
• Katena Products Inc.
• Merakris Therapeutics Inc.
• MiMedx Group Inc.
• Next Biosciences Pty Ltd.
• NuVision Biotherapies Ltd
• Organogenesis Holdings Inc.
• Orthofix Medical Inc.
• Reea carewell products
• Skye Biologics Holdings LLC
• Stryker Corp.
• Surgenex LLC
• SURGITECH INNOVATION
• TissueTech Inc.

Qualitative and quantitative analysis of companies has been conducted to help clients understand the wider business environment as well as the strengths and weaknesses of key market players. Data is qualitatively analyzed to categorize companies as pure play, category-focused, industry-focused, and diversified; it is quantitatively analyzed to categorize companies as dominant, leading, strong, tentative, and weak.

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Key Market Customer Landscape

The market forecasting report includes the adoption lifecycle of the market research and growth, covering from the innovator’s stage to the laggard’s stage. It focuses on adoption rates in different regions based on penetration. Furthermore, the report also includes key purchase criteria and drivers of price sensitivity to help companies evaluate and develop their market growth and forecasting strategies.

 Market Customer Landscape

Segment Overview

The market report forecasts market growth by revenue at global, regional & country levels and analyzes the latest trends and growth opportunities from 2017 to 2027. 

• End-user Outlook 
  • Hospitals
  • Ambulatory surgical centers
  • Specialty clinics
  • Research and academic institutes

• Type Outlook 
  • Cryopreserved amniotic membrane
  • Dehydrated amniotic membrane

• Region Outlook 
  • North America
    • The U.S.
    • Canada
  • Europe
    • The U.K.
    • Germany
    • France
    • Rest of Europe
  • Asia
    • China
    • India
  • Middle East & Africa
    • Saudi Arabia
    • South Africa
    • Rest of the Middle East & Africa
  • Asia
    • Australia
    • Argentina
    • Rest of the World 

Market Analyst Overview 

The market is experiencing substantial growth due to its wide-ranging applications in ophthalmology and wound care. Amniotic membrane transplants serve as effective biological bandages for treating ocular conditions like corneal ulcers, conjunctiva surface issues, and pterygium excisions. Additionally, they offer therapeutic benefits for burn wounds and chronic diseases, owing to their anti-inflammatory properties and tissue regeneration capabilities. With increasing adoption in ambulatory surgical centers and healthcare infrastructure, frozen amniotic membranes are becoming a preferred choice among healthcare professionals. As a result, the market is witnessing significant advancements in tissue engineering and biotechnology, catering to various surgical procedures and addressing diverse eye health concerns globally.

Further, the market is pivotal in addressing various medical needs, particularly in ophthalmology and wound care. Amniotic membrane-based products, such as biological bandages and surgical grafts, play a crucial role in treating conditions like pressure and venous leg ulcers, ocular dystrophy, and dry eye disease. These innovative solutions are widely utilized in ambulatory surgical centers (ASCs) and across the healthcare sector to combat non-communicable diseases, including cardiovascular diseases, chronic respiratory diseases, and cancer. With their anti-inflammatory properties and regenerative potential derived from human cells and amniotic tissues, these products offer promising outcomes, advancing eye care and wound management globally.

Market Scope
Report Coverage	Details
Page number	161
Base year	2022
Historic period	2017-2021
Forecast period	2023-2027
Growth momentum & CAGR	Accelerate at a CAGR of 14.6%
Market growth 2023-2027	USD 2.3 billion
Market structure	Fragmented
YoY growth 2022-2023(%)	12.65
Regional analysis	North America, Europe, Asia, and the Rest of the World (ROW)
Performing market contribution	North America at 56%
Key countries	US, Canada, Germany, UK, and France
Competitive landscape	Leading Companies, Market Positioning of Companies, Competitive Strategies, and Industry Risks
Key companies profiled	Amnio Technology LLC, Applied Biologics LLC, BIOHEALING SRO, Celularity Inc., Flower Orthopedics Corp., Human Regenerative Technologies LLC, Integra Lifesciences Corp., Katena Products Inc., Merakris Therapeutics Inc., MiMedx Group Inc., Next Biosciences Pty Ltd., NuVision Biotherapies Ltd, Organogenesis Holdings Inc., Orthofix Medical Inc., Reea carewell products, Skye Biologics Holdings LLC, Stryker Corp., Surgenex LLC, SURGITECH INNOVATION, and TissueTech Inc.
Market dynamics	Parent market growth analysis, Market growth inducers and obstacles, Fast-growing and slow-growing segment analysis, COVID-19 impact and recovery analysis and future consumer dynamics, and Market condition analysis for the market forecast period.
Customization purview	If our report has not included the data that you are looking for, you can reach out to our analysts and get segments customized.

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What are the Key Data Covered in this Market Research Report?

• CAGR of the market during the forecast period
• Detailed information on factors that will drive the growth of the market between 2023 and 2027
• Precise estimation of the size of the market size and its contribution to the market in focus on the parent market
• Detailed analysis of customer landscape covering Diver of price sensitivity, Adoption of the lifecycle, and key purchase criteria 
• Vendor landscape comparing criticality of inputs and factors of differentiation
• Exclusive Matrix on vendor position and Classification
• Accurate predictions about upcoming trends and changes in consumer behavior
• Growth of the market industry across North America, Europe, Asia, and the Rest of the World (ROW)
• A thorough analysis of the market’s competitive landscape and detailed information about companies
• Comprehensive analysis of factors that will challenge the growth of the market companies

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