This pipeline analysis report provides detailed insights into the clinical trial landscape of malaria therapeutics, including molecules at the pre-clinical and discovery stage. This malaria diagnostics market report also covers information about the therapeutic assessment of the pipeline molecules based on therapies employed, route of administration, target, mechanism of action (MoA), and therapeutic modalities. Also, the report provides an analysis of the companies currently involved in the development of pipeline molecules for malaria including Astellas Pharma Inc., Bharat Biotech Ltd., Carna Biosciences Inc., Eisai Co. Ltd., Lipotek Pty Ltd., Merck KGaA, Novartis AG, Nurex Srl, Sanaria Inc., Sanofi, Takeda Pharmaceutical Co. Ltd., and VLP Therapeutics.
Overview of the Therapeutic Pipeline for Malaria
It has been observed that children under five years of age are the most vulnerable group affected by malaria. Children with severe malaria very often develop one or more symptoms, including severe anemia, respiratory distress in relation to metabolic acidosis, or cerebral malaria. On the other hand, multi-organ failure is very common in adults with malaria. Although in malaria-endemic areas, people may develop partial immunity, allowing asymptomatic infections to occur, the demand for effective combination and intravenous therapeutics is increasing. The drugs are formulated to eliminate Plasmodium parasites, which causes the disease. Among the several Plasmodium species, P. falciparum is the most lethal if left untreated. Globally, the incidence and prevalence of malaria are decreasing every year. However, The WHO African Region continues to carry a disproportionately high share of the global malaria burden. In 2018, the region was home to 93% of malaria cases and 94% of malaria deaths.
Most of the molecules in the pipeline are being developed for monotherapy and oral route of administration. Over 35% of the molecules in the pipeline are currently in the discovery and pre-clinical stages. In addition to the active molecules, there are also a number of pipeline products that have been either discontinued from development or are currently dormant.
Companies Covered
This malaria diagnostics market report provides a detailed analysis of companies that are involved in the development of molecules for the treatment of malaria. The report provides information on the number of molecules currently developed by companies and the various stages of these molecules. The report also covers details on the collaboration of these companies with institutions to utilize the available technologies for further development and commercialization of molecules.
Some of the companies covered in this pipeline analysis report include -
- Astellas Pharma, Inc.
- Bharat Biotech Ltd.
- Carna Biosciences, Inc.
- Eisai Co. Ltd.
- Lipotek Pty Ltd.
- Merck KGaA
- Novartis AG
- Nurex Srl
- Sanaria Inc
- Sanofi
- Takeda Pharmaceutical Co. Ltd.
- VLP Therapeutics
Malaria - Pipeline Analysis: Therapeutic Assessment of the Molecules by RoA
- Oral
- Intramuscular
- Intravenous
- Unknown
The intramuscular route of administration (RoA) has more rapid onset action compared with oral administration. It is also more effective than intravenous molecules as a few drugs irritate the veins, and there are instances wherein the vein cannot be located. However, most of the molecules that are currently in the pipeline are being developed for oral administration.
Malaria - Pipeline Analysis: Therapeutic Assessment of the Molecules by Therapy
- Monotherapy
- Combination therapy
Monotherapy uses a single drug to treat a disorder. Most of the molecules that are currently in the pipeline to treat malaria are being developed as monotherapy drugs.
Malaria - Pipeline Analysis: Key Highlights of the Report
- What are the therapy molecules used in the various development stages of the parasite causing malaria?
- What are the companies that are currently involved in the development of therapeutic molecules for malaria?
- Insight into discontinued/dormant molecules with appropriate reasoning
- What are the major regulatory authorities approving drugs in various regions?
- Detailed profiling of each active molecule
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PART 01: Executive summary
PART 02: Scope
PART 03: Disease overview
- 1.2Introduction
- PART 04: Regulatory framework
PART 05: Drug development landscape
- 1.3Drugs under development
PART 06: Drug development strategies
- 1.4Therapies employed
- 1.5RoA
- 1.6Therapeutic modalities
- 1.7Targets for drug development
- 1.8Mechanism of action (MoA)
PART 07: Recruitment strategies
- 1.9Geographical coverage
- 1.10Recruitment status
- 1.11Gender of participants
- 1.12Age structure
- 1.13Recruitment volume
PART 08: Key companies
PART 09: Astellas Pharma, Inc.
PART 10: Bharat Biotech Ltd.
PART 11: Carna Biosciences, Inc.
1.18Overview
PART 12: Eisai Co. Ltd.
PART 13: Lipotek Pty Ltd.
PART 14: Merck KGaA
PART 15: Novartis AG
PART 16: Nurex Srl
PART 17: Sanaria, Inc.
- 1.27Overview
- 1.28PfSPZ Vaccine
PART 18: Sanofi
PART 19: Takeda Pharmaceutical Co. Ltd.
- 1.30Overview
- 1.31DSM265
- 1.32ELQ300
PART 20: VLP Therapeutics
PART 21: Dormant molecules
PART 22: Appendix
- 1.35List of abbreviations
Research Framework
Technavio presents a detailed picture of the market by way of study, synthesis, and summation of data from multiple sources. The analysts have presented the various facets of the market with a particular focus on identifying the key industry influencers. The data thus presented is comprehensive, reliable, and the result of extensive research, both primary and secondary.
INFORMATION SOURCES
Primary sources
- Manufacturers and suppliers
- Channel partners
- Industry experts
- Strategic decision makers
Secondary sources
- Industry journals and periodicals
- Government data
- Financial reports of key industry players
- Historical data
- Press releases
DATA ANALYSIS
Data Synthesis
- Collation of data
- Estimation of key figures
- Analysis of derived insights
Data Validation
- Triangulation with data models
- Reference against proprietary databases
- Corroboration with industry experts
REPORT WRITING
Qualitative
- Market drivers
- Market challenges
- Market trends
- Five forces analysis
Quantitative
- Market size and forecast
- Market segmentation
- Geographical insights
- Competitive landscape