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The amniotic membrane market size is estimated to grow by USD 2.72 billion at a CAGR of 15.19% between 2023 and 2028. Major market drivers include its extensive use in ophthalmic surgeries, wound repair, reconstruction, and regenerative medicine due to its anti-inflammatory and anti-scarring properties. Amniotic membranes are used for wound repair, reducing scarring, and minimizing infection risks, particularly in treating chronic ulcers and diabetic foot ulcers.
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Companies are implementing various strategies, such as strategic alliances, partnerships, mergers and acquisitions, geographical expansion, and product/service launches, to enhance their presence in the market. The report also includes detailed analyses of the competitive landscape of the market and information about key companies, including:
Amnio Technology LLC - The company offers amniotic membrane products such as chorion-free amniotic membranes.
Amnio Technology LLC, Applied Biologics LLC, BIOHEALING SRO, Celularity Inc., Flower Orthopedics Corp., Human Regenerative Technologies LLC, Integra Lifesciences Corp., Katena Products Inc., Merakris Therapeutics Inc., MiMedx Group Inc., Next Biosciences Pty Ltd., NuVision Biotherapies Ltd, Organogenesis Holdings Inc., Orthofix Medical Inc., Reea carewell products, Skye Biologics Holdings LLC, Stryker Corp., Surgenex LLC, SURGITECH INNOVATION, and TissueTech Inc.
Qualitative and quantitative analysis of companies has been conducted to help clients understand the wider business environment as well as the strengths and weaknesses of key market players. Data is qualitatively analyzed to categorize companies as pure play, category-focused, industry-focused, and diversified; it is quantitatively analyzed to categorize companies as dominant, leading, strong, tentative, and weak.
The market is witnessing significant growth driven by advancements in regenerative medicine and the increasing adoption of tissue-based products in medical treatments. With a focus on tissue regeneration and the rising prevalence of conditions such as pulmonary fibrosis, ocular diseases, and burn injuries, the demand for amniotic membrane treatments is on the rise. This market caters to various healthcare sectors, offering solutions for surgical wounds, traumatic injuries, and non-healing chronic wounds. The amniotic membrane's anti-inflammatory and antibacterial properties make it a valuable resource in wound care biologics, further enhancing its market potential in addressing diverse medical applications across the globe.
The market share growth by the hospitals segment will be significant during the forecast period. The market is a versatile biological material derived from the innermost layer of the placenta. Due to the unique characteristics of it, such as its ability to heal wounds with antimicrobial and bacterial activity, it has been applied in a variety of healthcare applications.
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The hospitals segment was valued at USD 758.20 million in 2018. There are a number of different uses for amniotic membranes in hospitals, In the case of eye surgery or eye care, it may be used as a graft to enhance wound healing, decrease scar tissue, and repair specific ophthalmological disorders. They have the potential for gynecological and obstetric applications such as repairing vaginal or cervical lacerations, promoting post-surgical healing, and treating conditions such as intrauterine adhesions. The use of the membranes in hospitals will drive the growth of the market focus during the forecast period.
Cryopreserved amniotic membranes are slow-freezes at -112 degrees Fahrenheit using preservation media such as Dulbeccos modified eagle medium (DMEM) and glycerol, which enables a slower rate of freezing without ice formation. Hesemeric membranes, during prolonged storage requirements, maintain the integrity of the amniotic membrane, as well as the local ECM architecture. The cryopreservation of key biological signalings proteins, such as the pentraxin 3 complex, fibronectin, collagen, and heavy chain hyaluronic acid present in ECM is helping to maintain their activity and quantity. The increasing coverage of cryopreserved products in reimbursement schemes of governments is promoting the demand for cryopreserved amniotic membranes. The number of tissue banks is also rising owing to the increasing availability of funding. Such a rise in capital funding helps tissue banks to enhance their storage capabilities and use the latest cryopreservation methods for membrane storage, thereby driving the growth of the segment during the forecast period.
Dehydrated amniotic membranes are preserved using a vacuum with low-temperature heat, which helps in retaining the devitalized cellular components. In contrast to cryopreserved membranes, dehydrated amniotic membranes can be stored and preserved at room temperature and, therefore, offer logistic benefits over cryopreserved amniotic membranes. Unlike cryopreserved membranes that are preserved for a period of 5 years, dehydrated membranes extend their shelf life up to 15 years. They in a variety of tissue sizes and thicknesses is being offered by several players on the market, according to medical needs. The low cost and low storage expense advantages over cryopreserved amniotic membranes, backed by the rising adoption of membranes in ophthalmic surgeries, are driving the growth of this segment. The cost of dehydrated membranes is 35% to 40% less compared with the costs of frozen membranes. In addition, at very low temperatures they are not dependent on specialized tissue banks for cryopreservation. Such benefits increase their preference for cryopreserved membranes in various surgical applications, which in turn accelerates the demand for the market
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North America is estimated to contribute 56% to the growth of the global market during the forecast period. Technavio’s analysts have elaborately explained the regional trends and drivers will shape the market during the forecast period.
North America is the most dominating region in the market, with the US as the leading country. The growth in the North America market is being driven by a growing acceptance of Advanced Wound Care treatments, due to increasing awareness about better healthcare options across people in the USA and Canada, as well as increases in demand for orthopaedics. The demand for the market as an advanced treatment for diabetic foot ulcers surged in the country as these products offered value-based and efficient treatment options by providing essential regenerative components to wound areas. This gave a boost to the revenue generated in the market in North America.
The market witnesses significant growth due to advancements in medical technology enabling amniotic transplants. Amniotic providers offer lyophilized amniotic tissue with anti-scarring properties, aiding in drug development and blood vessel regeneration. Amniotic allografts find applications in treating corneal epithelia damage. This market thrives on the rising demand for medical advancements leveraging the regenerative potential of amniotic tissue for various therapeutic purposes. Our researchers analyzed the data with 2023 as the base year, along with the key drivers, trends, and challenges.
The extensive use of amniotic membrane transplantation in ophthalmic surgeries is driving growth in the market. These transplantations have transformed the treatment of ophthalmic conditions, specifically treatments related to ocular surface reconstruction. Due to the characteristics of membranes enabling epithelial cells to migrate, strengthening cell adhesion, and encouraging epithelial diffraction, ocular surface reconstruction procedures have been significantly improved.
Moreover, the market can modulate stromal scarring and have anti-inflammatory properties. Consequently, for the treatment of bullous keratitis, glaucoma or cataract, peripheral limbic stem cell deficiency, persistent epithelium defects, and corneoscleral ulcers, there is a growing trend among ophthalmologists to use amniotic membrane transplantation in cornea surface reconstruction. The increasing number of ophthalmic surgeries is promoting the demand for membranes among end-users such as hospitals and clinics. About 45 million people in the US use contact lenses for vision correction. Such eye infections and disorders increase the demand for ophthalmic reconstruction surgeries across the globe, thereby driving the growth of the market focus during the forecast period.
The growing reimbursement coverage for new products is a primary trend in the market. Governments throughout the world are increasingly modifying their reimbursement structure for new health products, to provide value-based care. Tissue-engineered products such as amniotic membranes are considered highly expensive owing to the involvement of a considerable amount of direct and indirect costs in sourcing, storage, transfer, and application.
However, government organizations and market companies are focusing on reimbursing such costs and providing value-based care. This has led to the revision of reimbursement policies for membrane products. Suppliers are making information and guidance available on their websites, with a view to raising awareness of insurance coverage for different products. Such activities are reducing the cost of membranes and increasing awareness regarding coverage policies among patients and medical practitioners, which is expected to drive the growth of the market during the forecast years.
The issues related to preservation and contamination are major challenges in the market. End-users have observed reluctance to adopt the amniotic fluid transfer procedure due to fears of patients transmitting contagious diseases. An amniotic membrane is directly derived from amniotic sacs retrieved during cesarean and vaginal deliveries. Bacterial contaminants are commonly found in vaginal and placental areas that may contaminate the product. In addition, the presence of infectious diseases in a donor can transmit infections to his or her recipient. To avoid these events, companies must carry out serology checks at the time of storage of amniotic membranes.
Additionally, amniotic membranes are required to be stored efficiently before their transplantation. It is a challenging task for market companies and end users to store the membrane while ensuring optimal conditions. Issues that pose challenging sterile storage requirements for market companies and end-users that operate in emerging regions with a lack of advanced storage options. This hampers the revenue growth of companies, thereby declining the growth of the market in focus during the forecast period.
The market forecast report includes the adoption lifecycle of the market, covering from the innovator’s stage to the laggard’s stage. It focuses on adoption rates in different regions based on penetration. Furthermore, the market report also includes key purchase criteria and drivers of price sensitivity to help companies evaluate and develop their market forecasting and growth strategies.
Customer Landscape
The market research report provides comprehensive data (region-wise segment analysis), with forecasts and estimates in "USD Billion " for the period 2024-2028, as well as historical data from 2018 - 2022 for the following segments.
The market is a dynamic sector addressing various healthcare needs. With applications ranging from ophthalmology surgeries to orthopedics and cosmetic surgeries, it offers regenerative medicines derived from human cells for conditions like moderate to severe burns and dry eye disease. Utilizing surgical innovations and advanced technologies, amniotic allografts serve as biological bandages in surgical recovery. They find use in tissue transplants and burn treatments, promoting surgical subspecialties such as ophthalmology and sports medicine in healthcare facilities.
Furthermore, the market addresses diverse healthcare needs, including orthopedic surgeries and podiatry treatments. Amnioeffect in chronic diseases drives drug development technology utilizing frozen amniotic tissue for burn and pressure ulcer treatments. Clinical trials explore its efficacy in tissue transplants and ophthalmology procedures for corneal ulcers and Pterygium excisions. Utilizing living tissue donors, amniotic allografts serve as biological bandages in surgical wounds segments, meeting unmet healthcare needs with alternative technologies.
Market Scope |
|
Report Coverage |
Details |
Base year |
2023 |
Historic period |
2018 - 2022 |
Forecast period |
2024-2028 |
Growth momentum & CAGR |
Accelerate at a CAGR of 15.19% |
Market Growth 2024-2028 |
USD 2.72 billion |
Market structure |
Fragmented |
YoY growth 2023-2024(%) |
13.37 |
Regional analysis |
North America, Europe, Asia, and Rest of World (ROW) |
Performing market contribution |
North America at 56% |
Key countries |
US, Canada, Germany, UK, and France |
Competitive landscape |
Leading Vendors, Market Positioning of Vendors, Competitive Strategies, and Industry Risks |
Key companies profiled |
Amnio Technology LLC, Applied Biologics LLC, BIOHEALING SRO, Celularity Inc., Flower Orthopedics Corp., Human Regenerative Technologies LLC, Integra Lifesciences Corp., Katena Products Inc., Merakris Therapeutics Inc., MiMedx Group Inc., Next Biosciences Pty Ltd., NuVision Biotherapies Ltd, Organogenesis Holdings Inc., Orthofix Medical Inc., Reea carewell products, Skye Biologics Holdings LLC, Stryker Corp., Surgenex LLC, SURGITECH INNOVATION, and TissueTech Inc. |
Market dynamics |
Parent market analysis, Market growth inducers and obstacles, Fast-growing and slow-growing segment analysis, COVID-19 impact and recovery analysis and future consumer dynamics, Market condition analysis for the forecast period. |
Customization purview |
If our market report has not included the data that you are looking for, you can reach out to our analysts and get segments customized. |
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1 Executive Summary
2 Market Landscape
3 Market Sizing
4 Historic Market Size
5 Five Forces Analysis
6 Market Segmentation by End-user
7 Market Segmentation by Type
8 Customer Landscape
9 Geographic Landscape
10 Drivers, Challenges, and Opportunity/Restraints
11 Competitive Landscape
12 Competitive Analysis
13 Appendix
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