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The Global Base Editing Market size is forecast to increase by USD 307.66 million, at a CAGR of 15.1% between 2023 and 2028.
There has been an increase in applications of genome editing in therapeutics. In addition, researchers are working on new gene-based therapies to reduce the morbidity and mortality among HIV-infected patients. Moreover, base editing can provide therapeutic tools for this disease. Furthermore, CRISPR technologies can offer anti-retroviral therapies to inhibit the virus with reduced treatment interventions. Hence, such factors are positively impacting the market.
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The drug discovery and development segment is estimated to witness significant growth during the forecast period. The market growth of the drug discovery and development segment is fuelled by the growing pharmaceutical and biotechnology industry's increasing R&D expenditure and increasing research on molecular biology toward drug discovery and development. In addition, biotechnology and pharmaceutical companies are investing huge amounts in R&D activities for drug discovery of genetic diseases along with the increasing prevalence of neurological disorders.
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The drug discovery and development segment was the largest segment and was valued at USD 80.47 million in 2018. Moreover, the market players are focused on investments in genome editing for drug testing, high-throughput screening, and developing innovative drug formulations. In addition, there is an increase in focus on drug discovery and development by pharmaceutical and biotechnology companies as well as by research institutes for several diseases, propelling the demand for base editing services. Furthermore, base editing finds applications such as target classification, target authentication, and analyzing pathways, compound profiling, and toxicology studies, which are critical in drug discovery and development.
Hence, such factors are fueling the growth of this segment which, in turn, drives the market growth and forecasting during the forecast period. Additionally, market analysis and report indicate a positive outlook for the expansion of the drug discovery and development segment in the foreseeable future.
The market growth of the DNA base editing segment is fueled by the growing adoption of DNA sequencing. In addition, DNA sequencing is gaining prominence in many areas, including biology and other sciences, such as forensics, anthropology, and medicine, due to its increasing number of applications. Moreover, DNA sequencing has a wide range of applications that range from the determination of the entire genome of any organism to the sequencing of individual genes. Furthermore, DNA base editing is widely used in medicine to determine the risks of certain genetic diseases in patients and to identify specific infection-causing bacteria to decide on the correct antibiotic treatment, thereby reducing the risk of antibiotic resistance.
Hence, such factors are fueling the growth of this segment, which in turn drives the market growth and forecasting during the forecast period. Additionally, precision editing and targeted mutagenesis techniques in genome engineering contribute significantly to the advancement and expansion of the DNA base editing segment in various scientific and medical applications.
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North America is estimated to contribute 35% to the growth of the global market during the forecast period. Technavio’s analysts have elaborately explained the regional trends and drivers that will shape the market during the forecast period. The market growth in North America is fuelled by the huge investment in R&D activities for gene therapy, especially in the US. In addition, the region holds strong potential for base editing due to hundreds of clinical trials being performed in the region, more specifically in the US, to treat cancer, human immunodeficiency virus (HIV) acquired immunodeficiency syndrome (AIDS), and other diseases. Furthermore, incidences of cancer have increased significantly in countries across North America over the years. Therefore, the high incidence of various types of cancers has increased the demand for several treatment procedures. Hence, such factors have increased the demand for base editing, which, in turn, is anticipated to drive the growth of the market in North America during the forecast period.
Companies are implementing various strategies, such as strategic alliances, partnerships, mergers and acquisitions, geographical expansion, and product/service launches, to enhance their presence in the market. The report also includes detailed analyses of the competitive landscape of the market and information about 20 market companies, including:
Beam Therapeutics Inc: The company offers base editing solutions such as the REPAIR system for A to I editing and the RESCUE system for C to U editing.
Qualitative and quantitative analysis of companies has been conducted to help clients understand the wider business environment as well as the strengths and weaknesses of key market players. Data is qualitatively analyzed to categorize companies as pure play, category-focused, industry-focused, and diversified; it is quantitatively analyzed to categorize companies as dominant, leading, strong, tentative, and weak.
The base editing market represents a groundbreaking frontier in genetic engineering, offering precise tools for genome modification and gene editing. Leveraging technologies like Cas9 nuclease, base editing enables targeted alterations in DNA, facilitating therapeutic applications in precision medicine.
With its potential in gene correction and gene regulation, base editing holds promise for advancing cell therapy and other medical interventions. As the field evolves, stakeholders closely monitor market trends and analysis to identify emerging opportunities and challenges. Market research and growth initiatives drive innovation and foster collaboration within the industry.
Strategic planning is informed by market forecasting insights and market analysis reports, guiding stakeholders in navigating market growth and trends. Together, these efforts contribute to the sustainable development and expansion of the market.
A key factor shaping the market growth is the technological advancement in genome editing tools. Several technological advances in the CRISPR-Cas9 base editing technology support biological and biomedical research. For example, in June 2020, E. Merck KG and 10X Genomics jointly announced the development of a new option for biological experiments, which combines the genome-editing technology offered by E. Merck KG with the Feature Barcode technology from 10X Genomics for screening single cells using CRISPR libraries.
Moreover, CRISPR systems are derived from bacteria and need to be re-engineered for use in human cells. In addition, proxy-CRISPR provides a rapid and simple method to increase its use without the time-consuming task of re-engineering native CRISPR proteins, which makes proxy-CRISPR more efficient, flexible, and specific than CRISPR systems. Hence, the continuous advancements in base editing tools will fuel their adoption in biological and biomedical research, contributing to market growth analysis during the forecast period.
Inherent issues in genome editing are one of the key challenges hindering market growth. CRISPR technologies are crucial for base editing due to their simplicity and efficiency. However, it has several disadvantages which are negatively impacting the market. For instance, base editing is used to insert or delete DNA fragments that are mediated by the DNA repair mechanism activated by endonucleases like Cas9.
Moreover, as the quality of genome editing tools is yet to be optimized, targeted alleles may also carry additional modifications like multiple integrations of target vectors, deletions, and duplications of DNA fragments. Thus, as it is impossible to select the desired event while using CRISPR technology, it is challenging to perform experiments on human embryos. Hence, such factors are hindering the market growth during the forecast period.
The market report includes the adoption lifecycle of the market, covering from the innovator’s stage to the laggard’s stage. It focuses on adoption rates in different regions based on penetration. Furthermore, the report also includes key purchase criteria and drivers of price sensitivity to help companies evaluate and develop their growth strategies.
Global Base Editing Market Customer Landscape
The market report forecasts market growth by revenue at global, regional & country levels and provides an analysis of the latest trends and growth opportunities from 2018 to 2028.
Base Editing Market Scope |
|
Report Coverage |
Details |
Page number |
148 |
Base year |
2023 |
Historic period |
2018-2022 |
Forecast period |
2024-2028 |
Growth momentum & CAGR |
Accelerate at a CAGR of 15.1% |
Market Growth 2024-2028 |
USD 307.66 million |
Market structure |
Fragmented |
YoY growth 2023-2024(%) |
13.51 |
Regional analysis |
North America, Europe, Asia, and the Rest of the World (ROW) |
Performing market contribution |
North America at 35% |
Key countries |
US, Germany, UK, China, and Japan |
Competitive landscape |
Leading Vendors, Market Positioning of Vendors, Competitive Strategies, and Industry Risks |
Key companies profiled |
Beam Therapeutics Inc., Bio Palette Co. Ltd., Cellectis SA, Creative Biogene, Danaher Corp., EdiGene Inc., ElevateBio, Genkore Co. Ltd., GenScript Biotech Corp., Horizon Discovery Ltd., Intellia Therapeutics Inc., KromaTiD Inc., Maravai LifeSciences Holdings Inc., Merck KGaA, Pairwise Plants Services, PerkinElmer Inc, ProQR Therapeutics NV, QI Biodesign Biotechnology Co. Ltd., Shape Therapeutics Inc., and Synthego Corp. |
Market dynamics |
Parent market analysis, Market growth inducers and obstacles, Fast-growing and slow-growing segment analysis, COVID-19 impact and recovery analysis and future consumer dynamics, and Market condition analysis for the forecast period. |
Customization purview |
If our report has not included the data that you are looking for, you can reach out to our analysts and get segments customized. |
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1 Executive Summary
2 Market Landscape
3 Market Sizing
4 Historic Market Size
5 Five Forces Analysis
6 Market Segmentation by Application
7 Market Segmentation by Type
8 Customer Landscape
9 Geographic Landscape
10 Drivers, Challenges, and Trends
11 Vendor Landscape
12 Vendor Analysis
13 Appendix
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