Enjoy complimentary customisation on priority with our Enterprise License!
The optogenetics market size is forecast to increase by USD 804.4 million, at a CAGR of 18.55% between 2024 and 2028. Optogenetics, a revolutionary neuroscience technique, is gaining significant traction in the medical community for its ability to treat depression and other neurological disorders. This non-invasive method utilizes light to manipulate neuronal activity, offering a more precise alternative to traditional pharmacological interventions. The adoption of optogenetics in behavioral and neuroscience research is on the rise, driven by advancements in ultrafast laser tool technology. These lasers enable researchers to deliver light with high spatial and temporal resolution, enhancing the technique's efficacy and accuracy. The integration of optogenetics into clinical applications, such as depression treatment, holds great promise for improving patient outcomes and broadening the scope of neuroscience research.
For More Highlights About this Report, Request Free Sample
Light emitting diodes (LEDs) are pivotal in optogenetics, a field utilizing channelrhodopsin, halorhodopsin, and archaerhodopsin to manipulate neuronal activity. Calcium aequorin and Cameleon act as pH sensors within living tissue, aiding in the spatial precision of neural circuits. Through genetic engineering of cells and genes, scientists target specific proteins in membrane-gated neuronal circuits for therapeutic applications in medicine. This technology holds promise for treating mood disorders and Parkinson's disease, addressing social difficulties by regulating brain circuits with temporal precision. Cell targeting using optogenetics offers insights into complex neurological conditions, enhancing understanding of neuronal circuits associated with cognitive and motor functions. The advancements in optogenetics underscore its potential in both basic neuroscience research and clinical interventions, paving the way for future therapies with unprecedented precision and efficacy.
Key Market Driver
One of the key factors driving the global optogenetics market growth is its ability to treat depression, which was the most common life-threatening mental disorder in 2021. Further, the imposition of lockdowns worldwide confined the people into their houses for up to 90 to 120 days. The pandemic in 2020 also caused a global recession, which resulted in job losses. Such situations across the world have surged mental health condition such as depression. Common antidepressants are very effective in a few patients and show side effects in noradrenergic and serotonin neurotransmission in some people with 28% efficacy. Nearly 30%-40% of people are resistant to treatment for depression but can be treated with optogenetics. Optogenetics detects the basolateral amygdala neuron or their extension into the central amygdala circuits to reveal the characteristics of anxiety. Thus, the increased prevalence of depression and clinical trials for optogenetics to cure depression will support market growth in the forecast period.
SIgnificant Market Trend
Another key factor driving the global optogenetics market growth is technological advancements. Optogenetics provides millisecond-scale temporal precision, allowing the experimenter to keep pace with fast biological information processing (for instance, in probing the causal role of specific action potential patterns in defined neurons). Additionally, optogenetics represents an important case study in the value of ecological conservation, as many of the key tools of optogenetics arise from microbial organisms occupying specialized environmental conditions and in the importance of pure basic science. Moreover, new developments in optogenetics, such as wireless microchips, have enabled convenient treatment of conditions, including depression and Parkinson's disease. These advancements of brain mapping by optogenetics will further drive the market growth in the forecast period.
Major Market Challenge
One of the key challenges to the global optogenetics market growth is the lack of standardization. A proper standard is to be used to translate optogenetics from a tool for the investigation of model organisms to a therapeutic for the treatment of human diseases. At a minimum, to be applied for stimulation of neurons in human patients, an ideal optogenetic therapy would require a safe and efficient gene delivery vehicle, targeting of the gene delivery vehicle to the tissue of interest, and an optogenetic protein that is highly sensitive to light in the red to near-infrared wavelength range (to keep light doses low, maximize light penetration, and minimize photodamage). In addition, the delivery of light itself also becomes a major issue when dealing with humans and primates compared to more commonly used animal models such as rodents. Moreover, in proper standardization, the process becomes too costly and also requires a high level of skill, which will limit the market growth in the coming years.
The market forecasting report includes the adoption lifecycle of the market, covering from the innovator’s stage to the laggard’s stage. It focuses on adoption rates in different regions based on penetration. Furthermore, the report also includes key purchase criteria and drivers of price sensitivity to help companies evaluate and develop their market growth analysis strategies.
Customer Landscape
Companies are implementing various strategies, such as strategic alliances, partnerships, mergers and acquisitions, geographical expansion, and product/service launches, to enhance their presence in the market.
Bruker Corp. - The company offers solutions for optogenetics using a laser that triggers any opsin without crosstalk with a complete spectrum of laser wavelengths, under the brand name of Bruker.
The market research and growth report also includes detailed analyses of the competitive landscape of the market and information about key companies, including:
Qualitative and quantitative analysis of companies has been conducted to help clients understand the wider business environment as well as the strengths and weaknesses of key market players. Data is qualitatively analyzed to categorize companies as pure play, category-focused, industry-focused, and diversified; it is quantitatively analyzed to categorize companies as dominant, leading, strong, tentative, and weak.
The type 1 segments is estimated to witness significant growth during the forecast period. Type I segment of opsin has captured the highest market share in the global optogenetic market in 2023. This is attributed to the because Type I opsins (like channelrhodopsin, halorhodopsin, and archaerhodopsin) are used in optogenetics to switch on or off neuronal activity.
Get a glance at the market share of various regions Download the PDF Sample
The type 1 segments accounted for USD 381.60 million in 2018 and showed a gradual increase during the forecast period. Moreover, Type I opsins are preferred if the neuronal activity should be modulated at higher frequency, because they respond faster than type II opsins. This is because type I opsins are ion channels or proton/ion pumps and thus are activated by light directly, while type II opsins activate G-proteins, which then activate effector enzymes that produce metabolites to open ion channels. The opsins used most commonly in optogenetic fall under the category of Type I opsins and are referred to as rhodopsins, meaning that they contain both an opsin protein as well as a light-sensitive chromophore. When activated by light, opsins cause depolarization or hyperpolarization of the cell membrane, with resulting cellular excitation or silencing on a millisecond time scale. Thus, the above-mentioned advantages are expected to fuel the growth of the type I segment in the global optogenetic market during the forecast period.
For more insights on the market share of various regions Download PDF Sample now!
Europe is estimated to contribute 38% to the growth of the global market during the forecast period. Technavio’s analysts have elaborately explained the regional trends and drivers that shape the market during the forecast period. Another region offering significant growth opportunities to vendors is North America. North America has captured the highest market share in the global optogenetics market in 2023. This is attributed to the rising demand for light therapy treatment for chronic pain in the region. For instance, according to Montreal Neurological Institute, light treatment therapy can control virtually any type of neuron in the brain with pulses of light, thus making it precise in terms of timing and type of cells affected.
Thus, optogenetics has proved to have a much more targeted approach to chronic pain relief and other abnormal disorders than the conventional methods, which cannot be localized with the same precision as a light beam. For instance, according to the Parkinsons Foundation, there are currently 1 million people with Parkinsons disease. Further, it is expected to rise to 1.2 million by 2030. It is also estimated that 60,000 Americans are diagnosed with Parkinsons disease per year. As a result of the increasing number of cases of Parkinsons disease, a better treatment option will be required. Hence, boosting the growth of the optogenetics market in this region.
The market research report provides comprehensive data (region-wise segment analysis), with forecasts and estimates in "USD million " for the period 2024-2028, as well as historical data from 2018 - 2022 for the following segments.
You may also interested in below market reports:
1. Genetic Testing Market: Genetic Testing Market Analysis North America, Europe, Asia, Rest of World (ROW) - US, Germany, UK, Japan, France - Size and Forecast
2. Animal Genetics Market; Animal Genetics Market Analysis North America, Europe, Asia, Rest of World (ROW) - US, Germany, UK, France, China - Size and Forecast
3. Genetic Testing Market in APAC: Genetic Testing Market in APAC by Product and Application - Forecast and Analysis
Light emitting diodes (LEDs) are crucial components in optogenetics, enabling precise manipulation of neuronal activity through optogenetic tools like ChrimsonR and optogenetic actuators. These tools utilize genetically modified calcium indicators and voltage-sensitive fluorescent proteins to monitor neurotransmitter release and membrane-gated ion channels with high spatial precision in brain function studies. Research in retinal disease treatment focuses on light-sensitive proteins for conditions such as retinitis pigmentosa and retinal degeneration, employing 3D holographic stimulation systems in research institutions and universities funded by research funding agencies and government support. Advances in synthetic biology and viral vectors enhance optogenetic therapies for Parkinson's disease, mental illnesses, and neurostimulation disorders. Digital technologies facilitate remote monitoring and virtual collaborations in healthcare, addressing challenges like physician shortage and improving healthcare access. RFID and RTLS systems ensure safety in medical device regulatory standards, benefiting chronic diseases management and cardiovascular ailments pacing.
Market Scope |
|
Report Coverage |
Details |
Page number |
135 |
Base year |
2023 |
Historic period |
2018 - 2022 |
Forecast period |
2024-2028 |
Growth momentum & CAGR |
Accelerate at a CAGR of 18.55% |
Market growth 2024-2028 |
USD 804.4 million |
Market structure |
Fragmented |
YoY growth 2023-2024(%) |
15.19 |
Regional analysis |
North America, Europe, Asia, and Rest of World (ROW) |
Performing market contribution |
Europe at 38% |
Key countries |
US, Germany, Canada, UK, and China |
Competitive landscape |
Leading Companies, Market Positioning of Companies, Competitive Strategies, and Industry Risks |
Key companies profiled |
Addgene Inc., AHF analysentechnik AG, Axion BioSystems Inc., Bruker Corp., Coherent Inc., DIGITAL LIGHT INNOVATIONS, Doric Lenses, GenSight Biologics S.A., HUBNER GmbH and Co. KG, Inscopix Inc., Judges Scientific plc, Laserglow Technologies, Neurolux, Noldus Information Technology bv, Novanta Inc., Plexon Inc., Prizmatix Ltd., RPMC Lasers Inc., Shanghai Laser and Optics Century Co. Ltd., The Jackson Laboratory, and Thorlabs Inc. |
Market dynamics |
Parent market analysis, Market forecasting growth inducers and obstacles, Fast-growing and slow-growing segment analysis, COVID-19 impact and recovery analysis and future consumer dynamics, Market condition analysis for forecast period |
Customization purview |
If our market report has not included the data that you are looking for, you can reach out to our analysts and get segments customized. |
1 Executive Summary
2 Market Landscape
3 Market Sizing
4 Historic Market Size
5 Five Forces Analysis
6 Market Segmentation by Type
7 Customer Landscape
8 Geographic Landscape
9 Drivers, Challenges, and Opportunity/Restraints
10 Competitive Landscape
11 Competitive Analysis
12 Appendix
Get the report (PDF) sent to your email within minutes.
Get lifetime access to our
Technavio Insights
Quick Report Overview:
Cookie Policy
The Site uses cookies to record users' preferences in relation to the functionality of accessibility. We, our Affiliates, and our Vendors may store and access cookies on a device, and process personal data including unique identifiers sent by a device, to personalise content, tailor, and report on advertising and to analyse our traffic. By clicking “I’m fine with this”, you are allowing the use of these cookies. Please refer to the help guide of your browser for further information on cookies, including how to disable them. Review our Privacy & Cookie Notice.