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The global in-vitro and in-vivo micro electrode array market size is estimated to grow by USD 7.71 million at a CAGR of 4.86% between 2022 and 2027.
Micro electrode arrays based on complementary metal-oxide-semiconductor (CMOS) technology are known to enable fast and high-resolution measurements of electrical activity in cell or tissue cultures. In vitro, CMOS-based MEA has been used in a wide range of applications, from electrical stimulation to recording electrical activity. Moreover, the functionality of some CMOS-based in vivo MEAs has shown promise for in vitro applications. With such wide-ranging applications in areas such as biomedical research and diagnostics, and the immense potential for technological advancement, CMOS-based in vitro MEAs have recently become commercially available. Therefore, the wide application of in vitro CMOS-based MEA is anticipated to fuel the growth of the global in vitro and in vivo MEA market during the forecast period.
Technavio has segmented the market into End-user, Type, and Geography
It also includes an in-depth analysis of drivers, trends, and challenges. Our report examines historic data from 2017 to 2021, besides analyzing the current market scenario.
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The market share growth by the pharmaceutical/biotechnology companies segment will be significant during the forecast period. Some large pharmaceutical and biotech companies, as well as CROs, have developed the necessary infrastructure to conduct neuroscience experiments/research to test drug candidates. CROs range from basic to late-stage research, including R&D tasks such as genetic engineering, safety and efficacy testing in animal models, hit discovery and lead optimization, assay development, target validation, and human clinical trials.
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The pharmaceutical/biotech. comp. and CROs segment was valued at USD 14.22 million in 2017. The MEA system allows the study of neuronal maturation based on electrophysiological properties and also enables robust and easy recording of acute brain slices. Therefore, many pharmaceutical and biotech companies use MEA for their research needs. These factors imply significant growth opportunities for in vitro and in vivo MEAs in this segment. Therefore, the industrial laboratory and CRO segment is expected to drive the growth of the global in vitro and in vivo MEA market during the forecast period.
With the rising need for fast, cost-effective, and high-performance platforms for the simultaneous examination of multiple tissues or cells, multiwell MEA is being adopted more and more. Additionally, by introducing CMOS chip technology in multiwell MEAs. Market players can facilitate rapid, high-resolution electrical activity imaging in cell and tissue cultures. However, the multi-well MEA system has built-in optical excitation that can be independently controlled. Thus, they can selectively target different cell types in cultures or tissue samples. Such developments and integrations facilitate the adoption of multi-well MEAs. Therefore, the multiwell MEA segment is expected to grow significantly which will drive the global in vitro and in vivo micro electrodes market during the forecast period.
A single-well MEA system has only one culture well with appropriate electrodes for recording the electrical activity of cell or tissue cultures and for electrically stimulating the contents of the well. Vendors are grappling with issues specific to single-well MEAs such as arrays determined by the number of connections available and signal degradation by adding new biochips with fully integrated digital and analog circuits realized in industrial complementary metal oxide semiconductor (CMOS) process size. Therefore, the single-well MEA segment is expected to account for a smaller proportion of the global in vitro and in vivo micro electrodes market during the forecast period.
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North America is estimated to contribute 50% to the growth of the global market during the forecast period. Technavio’s analysts have elaborately explained the regional trends and drivers that will shape the market during the forecast period. A significant number of people in North America suffer from neurological and psychiatric disorders such as Alzheimer's disease, Parkinson's disease, depression, sleep disorders, epilepsy, stroke, traumatic brain injury, and migraines. As a result, government agencies are advancing their understanding of neuroscience and funding various projects focused on finding cures for brain diseases.
Furthermore, the large number of clinical trials being conducted in the region has raised the demand for in vitro and in vivo MEAs for drug screening and testing across North America. In vitro and in vivo MEAs have found wide application in drug discovery and evaluation of the safety and efficacy of new therapeutics. Therefore, with a large number of clinical trials being conducted in the US, the demand for in vitro and in vivo MEAs in this region will further increase. In addition, the high prevalence of brain diseases in the region necessitates significant expenditure on related medical care. Therefore, such factors are expected to drive the North American in vitro and in vivo MEA market during the forecast period.
In 2020, the outbreak of COVID-19 had a negative impact on the in-vitro and in-vivo MEA market in North America. However, in 2021, the initiation of large-scale vaccination drives?lifted the lockdown restrictions. There is optimism that MEA R&D will revive as North America recovers from the pandemic. The region's focus on adaptability and scientific advances will catalyze innovative solutions to address emerging challenges, driving the growth of the North American in vitro and in vivo MEA market during the forecast period.
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Companies are implementing various strategies, such as strategic alliances, partnerships, mergers and acquisitions, geographical expansion, and product/service launches, to enhance their presence in the market. The report also includes detailed analyses of the competitive landscape of the market and information about 20 market companies, including:
Qualitative and quantitative analysis of companies has been conducted to help clients understand the wider business environment as well as the strengths and weaknesses of key market players. Data is qualitatively analyzed to categorize companies as pure play, category-focused, industry-focused, and diversified; it is quantitatively analyzed to categorize companies as dominant, leading, strong, tentative, and weak.
There are multiple factors influencing market growth. Our researchers analyzed the data with 2022 as the base year, along with the key drivers, trends, and challenges.
The extensive use of MEAs in neuroscience research is the key driver for the growth of the market. MEA is currently the most important approach to studying neuronal pathology, physiology, and circuit connectivity under both in vitro and in vivo conditions. Technologies such as deep brain stimulation have proven effective in treating neurodegenerative disorders that cause movement disorders such as Parkinson's disease. Moreover, MEA has demonstrated not only its efficacy in providing insights into processes such as memory formation and cognition, but also its potential therapeutic value for indications such as depression, epilepsy, and obsessive-compulsive disorder.
Furthermore, recent research has begun to take full advantage of HDMEA's special features. HDMEA can be used to perform complex neuronal culture analyses, such as estimating functional connections and tracking burst patterns. Therefore, extensive use of MEA in neuroscience research is expected to drive the global in vitro and in vivo MEA market during the forecast period.
The emergence of neurostimulation devices is the primary trend in the market. Due to advances in neuroscience, in vivo and in vitro neuromodulatory devices such as MEAs are expected to gain clinical relevance in the coming years, generating increasing interest from clinicians, healthcare systems, patients, industry, and payers. Studies suggest that the MEA approach, both in vitro and in vivo, can be used for neurostimulation, and its application is on the horizon, especially in undertreated indications such as depression, epilepsy, and migraine.
Although MEAs have been used to study the effects of drugs on electrical activity in cell and tissue cultures, there is a growing patient preference for non-drug options for treating various brain-related diseases. Therefore, the demand for in vivo and in vitro MEAs is expected to increase during the forecast period due to the increasing number of research studies involving MEAs for neurostimulation.
Limitations of MEAs is a challenge that affects the growth of the market. Numerous research studies have been performed using advanced MEAs such as in vitro CMO-based HDMEA. However, in vitro MEAs lack high spatial resolution compared to dynamic clamp and patch clamp systems, making them less suitable for single-cell stimulation and recording. The ability of MEAs to effectively transmit complex signals to other cells is limited compared to dynamic clamps.
Furthermore, MEA implantation, especially chronic implantation, provokes a number of biological responses, including a decreased number of functioning electrodes, glial scarring, and neuronal cell loss. These responses depend on factors such as MEA stem size, stem-to-stem spacing, MEA material composition, and insertion time. Such restrictions seriously undermine the effectiveness of the MEA, thereby limiting its acceptability. Thus, MEA limitations are expected to impede the growth of the market during the forecast period.
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The market report includes the adoption lifecycle of the market, covering from the innovator’s stage to the laggard’s stage. It focuses on adoption rates in different regions based on penetration. Furthermore, the report also includes key purchase criteria and drivers of price sensitivity to help companies evaluate and develop their growth strategies.
Global In-Vitro and In-Vivo Micro Electrode Array Market Customer Landscape
The in-vitro and in-vivo micro electrode array market report forecasts market growth by revenue at global, regional & country levels and provides an analysis of the latest trends and growth opportunities from 2017 to 2027.
In-Vitro and In-Vivo Micro Electrode Array Market Scope |
|
Report Coverage |
Details |
Page number |
154 |
Base year |
2022 |
Historic period |
2017-2021 |
Forecast period |
2023-2027 |
Growth momentum & CAGR |
Accelerate at a CAGR of 4.86% |
Market growth 2023-2027 |
USD 7.71 million |
Market structure |
Fragmented |
YoY growth 2022-2023(%) |
4.03 |
Regional analysis |
North America, Europe, Asia, and Rest of World (ROW) |
Performing market contribution |
North America at 50% |
Key countries |
US, UK, Germany, France, and Japan |
Competitive landscape |
Leading Vendors, Market Positioning of Vendors, Competitive Strategies, and Industry Risks |
Key companies profiled |
3Brain AG, Alpha Omega Engineering Ltd., Axion BioSystems Inc., Blackrock Microsystems Inc., Cambridge NeuroTech, FHC Inc., Harvard Bioscience Inc., IMEC Inc., Innovative Neurophysiology Inc., MaxWell Biosystems AG, Microprobes for Life Science, MICRUX FLUIDIC S.L., NeuroNexus Technologies Inc., NMI Technologie Transfer GmbH, Plexon Inc., Ripple Neuro, Screen Holdings Co. Ltd., SpikeGadgets, Tucker Davis Technologies, and World Precision Instruments |
Market dynamics |
Parent market analysis, Market growth inducers and obstacles, Fast-growing and slow-growing segment analysis, COVID-19 impact and recovery analysis and future consumer dynamics, Market condition analysis for the forecast period. |
Customization purview |
If our report has not included the data that you are looking for, you can reach out to our analysts and get segments customized. |
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1 Executive Summary
2 Market Landscape
3 Market Sizing
4 Historic Market Size
5 Five Forces Analysis
6 Market Segmentation by End-user
7 Market Segmentation by Type
8 Customer Landscape
9 Geographic Landscape
10 Drivers, Challenges, and Trends
11 Vendor Landscape
12 Vendor Analysis
13 Appendix
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