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The protein A resin market size is estimated to grow by USD 721.6 million at a CAGR of 10.03% between 2023 and 2028. Monoclonal antibodies (mAbs) have gained significant attention in the biotechnology industry due to their increasing use in various therapeutic applications. The global market for mAbs is projected to grow at a robust rate, driven by the rising demand for therapeutic antibodies. This trend is further fueled by the growing demand for disposable pre-packed columns, which facilitate the large-scale production of mAbs with improved efficiency and cost-effectiveness. mAbs are essential in diagnosing and treating various diseases, including cancer and autoimmune disorders. Their high specificity, stability, and ability to target specific antigens make them an ideal choice for developing novel therapeutics. The growing pipeline of mAb-based therapies and the increasing investment in research and development are expected to further drive the growth of this market.
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The Market is witnessing significant growth due to its extensive applications in the pharmaceutical industries, particularly in the production of protein engineered products such as vaccines and therapeutics. Protein A resin is widely used in chromatography for the purification of monoclonal antibodies, which are essential in the treatment of various chronic ailments including oncology, neurological disorders, autoimmune disorders, and inflammatory disorders. The increasing demand for monoclonal antibodies in drug discovery and manufacturing facilities is driving the growth of the market. The biopharmaceutical domain is experiencing a shift towards the production of gene therapies, which also requires protein A resin for the purification of nucleic acids and antibodies. The geriatric population is another significant factor fueling the market growth, as they are more susceptible to chronic ailments and autoimmune conditions. The presence of anionic impurities in monoclonal antibody production necessitates the use of protein A resin for their removal. Synthetic biology and bioprocessing facilities are also adopting protein A resin for the production of therapeutic proteins. Endotoxins are common contaminants in biopharmaceutical manufacturing, and protein A resin is effective in their removal, making it an indispensable tool in the industry. Our researchers analyzed the data with 2023 as the base year, along with the key drivers, trends, and challenges. A holistic analysis of drivers will help companies refine their marketing strategies to gain a competitive advantage.
Increasing demand for monoclonal antibodies (mAbs) is notably driving market growth. In the biopharmaceutical domain, the analysis of complex mixtures, particularly in the context of biomanufacturing and bioprocessing facilities, requires the application of appropriate chromatography techniques. The geriatric population's increasing prevalence of chronic ailments, autoimmune conditions, and cancer necessitates advanced biopharmaceutical research to develop effective treatments. Protein A resin, a popular chromatography medium, plays a crucial role in this regard.
However, the selection of this technique necessitates consideration of the chemical composition, nature, chemical and physical properties, and physical state of the target substance. The lack of skilled professionals proficient in chromatography equipment and operations poses a challenge to the biopharmaceutical industry. Contract Manufacturing Organizations (CMOs) are increasingly outsourcing protein A resin-based purification processes to mitigate this issue. The biotechnology industry's growing emphasis on gene therapies further underscores the importance of protein A resin in the biopharmaceutical research and manufacturing landscape. Thus, such factors are driving the growth of the market during the forecast period.
Increasing demand for biosimilars is the key trend in the market. The market holds significant importance in the biopharmaceutical domain, particularly in the context of the growing demand for biotherapeutics and biosimilars. With an aging population and a rise in chronic ailments, autoimmune conditions, and cancer, the need for advanced bioprocessing solutions is increasingly crucial. Manufacturing facilities and biomanufacturing capacities require sophisticated bioanalytical tools to ensure comprehensive characterization of biotherapeutic proteins. Glycosylation, phosphorylation, oxidation, sulfation, disulfide linkages, glycation, mutation, proteolytic clipping, and deamidation are essential features that need to be analyzed during the development phase of biologics and biosimilars.
These analyses are critical for full sequence coverage, quantification, purity assessment, and product identification. Biopharmaceutical research and gene therapies further intensify the demand for high-resolution and sensitive bioanalytical methods. Contract Manufacturing Organizations (CMOs) play a pivotal role in catering to the analytical requirements of the biopharmaceutical industry. Protein A Resin, with its ability to capture IgG proteins, is a vital tool in this context, ensuring the production of high-quality therapeutic proteins. Thus, such trends will shape the growth of the market during the forecast period.
Lack of skilled professionals is the major challenge that affects the growth of the market. In the biopharmaceutical domain, the demand for Protein A Resin in the chromatographic separation of biomolecules is escalating due to the increasing research and development activities in biomanufacturing capacities and bioprocessing facilities. The geriatric population's prevalence to chronic ailments, autoimmune conditions, and cancer necessitates the production of gene therapies and biopharmaceuticals. Protein A Resin's application in capturing monoclonal antibodies is crucial in this regard.
However, the dearth of skilled professionals proficient in Protein A Resin technology poses a challenge to the industry. This situation necessitates collaborations with Contract Manufacturing Organizations (CMOs) to ensure the timely delivery of high-quality products. The selection of Protein A Resin as the chromatographic technique for biopharmaceutical research is vital for the purification process. The appropriate application of this technique can save costs and reduce the time to market, while an incorrect choice may result in additional expenses. Hence, the above factors will impede the growth of the market during the forecast period
The market forecasting report includes the adoption lifecycle of the market, covering from the innovator’s stage to the laggard’s stage. It focuses on adoption rates in different regions based on penetration. Furthermore, the report also includes key purchase criteria and drivers of price sensitivity to help companies evaluate and develop their market growth analysis strategies.
Customer Landscape
Companies are implementing various strategies, such as strategic alliances, partnerships, mergers and acquisitions, geographical expansion, and product/service launches, to enhance their presence in the market.
Ecolab Inc. - The company offers protein A affinity and ion-exchange chromatography resins that deliver exceptional purification of complex biologics, up to 500 kDa.
The market research and growth report also includes detailed analyses of the competitive landscape of the market and information about key companies, including:
Qualitative and quantitative analysis of companies has been conducted to help clients understand the wider business environment as well as the strengths and weaknesses of key market players. Data is qualitatively analyzed to categorize companies as pure play, category-focused, industry-focused, and diversified; it is quantitatively analyzed to categorize companies as dominant, leading, strong, tentative, and weak.
The market share growth by the Recombinant protein A segment will be significant during the forecast period. Recombinant protein A, a manipulated form of protein, is generated through recombinant technology in specialized vehicles called vectors. This process is widely used in life sciences, particularly in pharmaceutical industries for producing protein engineered products, such as vaccines and therapeutics. In chromatography, recombinant protein A is employed for the purification of monoclonal antibodies used in oncology, neurological disorders, autoimmune disorders, and inflammatory disorders.
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The Recombinant protein A segment showed a gradual increase in the market share of USD 547.60 million in 2018. Anionic impurities, nucleic acids, endotoxins, and other contaminants are effectively removed during the purification process using protein A resins. Recombinant protein A is also used in drug discovery applications for the production of biosimilars during patent expiry, as well as in the purification of biologics and antibody production. Synthetic biology and immunoprecipitation applications further expand its usage. Contract manufacturers and research organizations leverage recombinant protein A in fermentation, extraction, and purification stages of the drug discovery process. Metal dopant absorption and pH levels are crucial factors in the production of recombinant protein A resins. Recombinant protein A is also used in the production of monoclonal antibodies and biosimilar antibodies, such as Leronlimab. Overall, the biopharmaceutical and biotechnology industries rely on recombinant protein A for its versatility and effectiveness in various applications.
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North America is estimated to contribute 44% to the growth of the global market during the forecast period. Technavio’s analysts have elaborately explained the regional trends and drivers that shape the market during the forecast period.
The market plays a pivotal role in the pharmaceutical industries, particularly in the production of protein engineered products, such as vaccines and therapeutics. Chromatography, a common technique in biopharmaceutical processes, utilizes Protein A resins for the purification of monoclonal antibodies, including those used in oncology, neurological disorders, autoimmune disorders, and inflammatory disorders. These resins specifically bind to Fc regions of IgG antibodies, facilitating their separation from other impurities, such as anionic impurities, nucleic acids, and endotoxins. Protein A resins are also crucial in drug discovery applications, where they aid in the purification of recombinant proteins, including albumin and transferrin, using various methods like fermentation, extraction, and purification. Contract manufacturers and research organizations rely on these resins for the production of biosimilars during patent expiry, ensuring the continuity of biologics in the market. Immunoprecipitation applications and the production of biosimilar antibodies, such as Leronlimab, further expand the market's scope. The biotechnology industries continue to explore the potential of synthetic biology and drug discovery processes, further fueling the demand for Protein A resins.
The market research report provides comprehensive data (region-wise segment analysis), with forecasts and estimates in "USD million " for the period 2024-2028, as well as historical data from 2018-2022 for the following segments.
Affinity Chromatography Reagents Market by Application, End-user and Geography - Forecast and Analysis
Immunoprecipitation Market Analysis North America, Europe, Asia, Rest of World (ROW) - US, Canada, UK, Germany, China - Size and Forecast
Ion Exchange Resins Market Analysis APAC, North America, Europe, South America, Middle East and Africa - US, China, India, Japan, Germany - Size and Forecast
The market is witnessing significant growth due to its extensive applications in the pharmaceutical industries, particularly in the production of protein engineered products such as vaccines and therapeutics. Protein A resin is widely used in chromatography, a technique employed for the purification of monoclonal antibodies, which are essential in the treatment of various diseases including oncology, neurological disorders, autoimmune disorders, and inflammatory disorders. Protein A resin is effective in binding to Fc region of IgG antibodies, making it an ideal choice for the purification of monoclonal antibodies. The increasing demand for biosimilars and the approaching patent expiry of several biologics is expected to further boost the market growth. The market is segmented into resins, applications, and end-users.
Furthermore, the resins segment includes albumin and transferrin, while the applications segment includes drug discovery applications, immunoprecipitation, and biosimilar antibodies. The end-users segment includes contract manufacturers, contract research organizations, and biopharmaceutical and biotechnology industries. The market growth is driven by the increasing demand for antibody purification, the drug discovery process, and the advancements in synthetic biology. Additionally, the market is also influenced by factors such as metal dopant absorption, pH levels, and the use of recombinant protein resins. Some of the key players in the market include Leronlimab, Fermentation, Extraction, Purification, and Drug discovery process providers.
Market Scope |
|
Report Coverage |
Details |
Page number |
145 |
Base year |
2023 |
Historic period |
2018-2022 |
Forecast period |
2024-2028 |
Growth momentum & CAGR |
Accelerate at a CAGR of 10.03% |
Market growth 2024-2028 |
USD 721.6 million |
Market structure |
Fragmented |
YoY growth 2023-2024(%) |
8.88 |
Regional analysis |
North America, Europe, Asia, and Rest of World (ROW) |
Performing market contribution |
North America at 44% |
Key countries |
US, China, Germany, Canada, and UK |
Competitive landscape |
Leading Companies, Market Positioning of Companies, Competitive Strategies, and Industry Risks |
Key companies profiled |
Abcam plc, Agarose Bead Technologies SL, Agilent Technologies Inc., Avantor Inc., Bio Rad Laboratories Inc., Bio-Works Technologies AB, Danaher Corp., Ecolab Inc., General Electric Co., GenScript Biotech Corp., JSR Corp., Kaneka Corp., Merck KGaA, Novasep Holding SAS, Orochem Technologies Inc., Perkin Elmer Inc., Repligen Corp., Takara Bio Inc., Thermo Fisher Scientific Inc., and Tosoh Corp. |
Market dynamics |
Parent market analysis, Market Forecasting, Market growth inducers and obstacles, Fast-growing and slow-growing segment analysis, COVID-19 impact and recovery analysis and future consumer dynamics, Market condition analysis for market forecast period |
Customization purview |
If our report has not included the data that you are looking for, you can reach out to our analysts and get segments customized. |
1 Executive Summary
2 Market Landscape
3 Market Sizing
4 Historic Market Size
5 Five Forces Analysis
6 Market Segmentation by Type
7 Customer Landscape
8 Geographic Landscape
9 Drivers, Challenges, and Opportunity/Restraints
10 Competitive Landscape
11 Competitive Analysis
12 Appendix
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