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The human liver models market size is forecast to increase by USD 3.46 billion at a CAGR of 20% between 2023 and 2028. The market is experiencing significant growth due to the increasing prevalence of liver diseases worldwide. According to the World Health Organization, liver diseases are the 11th leading cause of death globally. Technological advancements in human organ modeling, such as the development of 3D-printed liver models and organ-on-chip technology, are revolutionizing research and drug development in this field. However, the lack of adequate healthcare infrastructure in developing nations poses a challenge to the market's growth. Despite this, the market is expected to continue expanding due to the high demand for accurate and efficient liver models for research and drug development purposes. Additionally, the rising geriatric population and increasing awareness of liver diseases are further fueling market growth. The market report forecast market size, historical data spanning from 2018 - 2022, and future projections, all presented in terms of value in USD million for each of the mentioned segments.
The human liver model market is gaining significant traction in the healthcare landscape due to the increasing incidences of organ transplants, Chronic Disease Management, and chronic liver conditions. Organ shortages have led researchers to explore alternative solutions for patient care, particularly in the context of liver diseases such as alcoholic liver disease, viral hepatitis, Cell Culture, hepatocellular carcinoma (HCC), and chronic liver diseases. Human liver models, including mini-organs and organoids, are being developed using advanced technologies like 3D printing technology to replicate the internal anatomy and molecular layer of the liver. These models offer advantages over animal-based models in terms of reducing toxicity and improving drug testing accuracy. Liver failure, caused by underlying medical conditions and liver diseases like hepatitis B and C, can be better understood and treated using these human liver models. Organ printing technologies are expected to revolutionize the field of liver research and patient care, providing a more accurate representation of human liver physiology.
The market research report provides comprehensive data (region-wise segment analysis), with forecasts and estimates in "USD million" for the period 2024-2028, as well as historical data from 2018 - 2022 for the following segments.
The liver organoids segment is estimated to witness significant growth during the forecast period. The healthcare landscape is witnessing a significant shift towards advanced organ transplant technologies to address organ shortages and enhance patient care. Three-dimensional (3D) printing technology and human organoids are revolutionizing the medical industry, providing potential solutions for chronic liver conditions such as alcoholic liver disease, viral hepatitis, liver cancer, and other diseases caused by unhealthy diets, sedentary lifestyles, alcohol consumption, and viral infections. Human Liver Models, fabricated using bio printing and 3D-engineered tissues, offer improved cell density, viability, and fabrication resolution compared to traditional 2D models.
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The liver organoids segment accounted for USD 845.10 million in 2018. These models are increasingly used for drug development, regenerative medicine, and toxicology testing in pharmaceutical research, enabling researchers to assess hepatotoxicity, drug metabolism, drug-drug interactions, and organ-on-a-chip technology for disease modeling and personalized medicine. The regulatory environment continues to evolve, supporting the use of these advanced models in biopharmaceuticals, further driving market growth. Key applications include modeling underlying medical conditions like liver disease and hepatocellular carcinoma, as well as chronic liver diseases.
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North America is estimated to contribute 42% to the growth of the global market during the market forecast period. Technavio's analysts have elaborately explained the regional trends and drivers that shape the market during the forecast period.
The healthcare landscape is witnessing a significant shift towards advanced organ transplant solutions due to organ shortages and the growing prevalence of liver diseases. Chronic liver conditions, including alcoholic liver disease, viral hepatitis, and liver cancer, are on the rise, fueled by unhealthy diets, sedentary lifestyles, alcohol consumption, and viral infections. The Human Liver Model, a promising alternative, is gaining traction in the research community as a potential solution for drug development and regenerative medicine. 3D Cell Culture, 3D printing technology, specifically bio printing and 3D-engineered tissues, is revolutionizing the field. These models offer superior cell density, viability, and fabrication resolution compared to traditional 2D models. Pharmaceutical research and toxicology testing are major applications for these models, enabling accurate hepatotoxicity testing and drug metabolism studies. The regulatory environment is evolving to accommodate these in vitro models, with increasing acceptance for personalized medicine and biopharmaceuticals. Organ-on-a-chip technology and disease modeling are key areas of focus, providing insights into underlying medical conditions and drug-drug interactions. In the context of liver disease, these models offer significant potential for understanding hepatocellular carcinoma and chronic liver diseases, ultimately improving patient care.
Our researchers analyzed the data with 2023 as the base year, along with the key drivers, trends, and challenges. A holistic analysis of drivers will help companies refine their marketing strategies to gain a competitive advantage.
The increasing prevalence of liver diseases is notably driving market growth. The liver plays a crucial role in human health, and disorders such as hepatitis B and C, type-2 diabetes, and metabolic disorders increase the risk of liver diseases, including liver fibrosis, cirrhosis, and liver cancer. Hepatitis B and C are significant contributors to liver cancer, accounting for over 70% of cases in the US. Approximately 31,000 Americans are diagnosed with liver cancer each year. The rise in lifestyle diseases, such as obesity and non-alcoholic fatty liver disease, further increases the risk of liver cancer. To address these challenges, advanced liver models, such as organ printing technologies, liver-on-a-chip, bioengineered systems, and liver organoids, are gaining popularity in research and medication development. These models offer a more accurate representation of human liver physiology than animal-based models. They enable drug discovery, chemoprevention, and toxicity testing, reducing the need for animal testing.
Further, research investments and venture capital funding in these areas have been increasing, with a focus on developing multi-organs-on-chips and human-on-a-chip platforms. These systems can simulate the internal anatomy and molecular layers of multiple organs, providing a more comprehensive understanding of drug interactions and medication development. The use of these advanced liver models in diagnosing liver infections and liver failure, as well as developing new therapeutic drugs, is expected to revolutionize the field of liver research and drug discovery. Thus, such factors are driving the growth of the market during the forecast period.
The technological advancements in human organ model is the key trend in the market. Three-dimensional (3D) tissue and organ models have gained significant attention in the scientific community due to their ability to better represent the intricate spatial and biological complexity of living tissues. These models offer more accurate assessments of therapeutic efficacy and safety, reducing the cost and ethical concerns associated with animal testing in drug discovery. Human cells-based 3D models, including liver models, have emerged as powerful platforms for tissue regeneration, organ transplantation and repair, drug screening, and in vitro disease modeling.
Moreover, techniques such as organoid culture, 3D bioprinting, microfluidics, organ-on-a-chip platforms, and functional biomaterials for tissue engineering have been developed to create these mini-organs. These advanced models are particularly relevant for studying liver diseases such as Hepatitis B, Hepatitis C, liver fibrosis, cirrhosis, and Type-2 diabetes, as well as metabolic disorders and liver infections. Moreover, these models can be used for medication development, diagnostics, and toxicology testing, making them essential tools for research programs receiving increased venture capital funding and investments. Thus, such trends will shape the growth of the market during the forecast period.
The lack of adequate healthcare infrastructure in developing nations is the major challenge that affects the growth of the market. The market is witnessing significant growth due to the increasing prevalence of liver-related diseases such as Hepatitis B, Hepatitis C, Type-2 diabetes, and metabolic disorders. Advanced liver models, including organ printing technologies and bioengineered systems like Liver-on-a-Chip and liver organoids, are gaining popularity in drug discovery and chemoprevention research. These models offer a more accurate representation of human liver physiology compared to animal-based models, reducing the reliance on animal testing.
Moreover, these models are essential for diagnosing drug toxicity and liver infections, enabling the development of therapeutic drugs and medication development. Organ-on-a-chip platforms and multi-organs-on-chips are also gaining traction due to their ability to mimic the internal anatomy and molecular layers of human organs. These technologies are crucial for understanding the complex interactions between various organs and the impact of medications on the body. Research programs and venture capital funding in the field of 3D bioprinting are increasing, providing opportunities for the development of mini-organs and human-on-a-chip models. However, the high cost of these advanced models and the lack of regulatory frameworks for their use are major challenges. Despite these challenges, the potential benefits of these models in drug discovery and personalized medicine are significant, making them a promising area for future investments. Hence, the above factors will impede the growth of the market during the forecast period.
The market forecasting report includes the market's adoption lifecycle, covering the innovator's stage to the laggard's stage. It focuses on adoption rates in different regions based on penetration. Furthermore, the report also includes key purchase criteria and drivers of price sensitivity to help companies evaluate and develop their market growth analysis strategies.
Customer Landscape
Companies are implementing various strategies, such as strategic alliances, partnerships, mergers and acquisitions, geographical expansion, and product/service launches, to enhance their presence in the market.
BioIVT LLC - The company offers human liver model namely Human Liver S9.
The market research and growth report also includes detailed analyses of the competitive landscape of the market and information about key companies, including:
Qualitative and quantitative analysis of companies has been conducted to help clients understand the wider business environment as well as the strengths and weaknesses of key market players. Data is qualitatively analyzed to categorize companies as pure play, category-focused, industry-focused, and diversified; it is quantitatively analyzed to categorize companies as dominant, leading, strong, tentative, and weak.
The human liver model market is witnessing significant growth due to the increasing prevalence of organ shortages and the need for advanced patient care in organ transplants. The healthcare landscape is shifting towards the use of 3D printing technology to create human liver models for addressing chronic liver conditions such as alcoholic liver disease, viral hepatitis, liver cancer, and other diseases caused by unhealthy diets, sedentary lifestyles, alcohol consumption, and viral infections. These models are essential for drug development in regenerative medicine and bio printing of 3D-engineered tissues with high cell density, viability, and fabrication resolution. Pharmaceutical research and toxicology testing are major applications of these models, enabling hepatotoxicity testing, drug metabolism, and drug-drug interaction studies. In vitro models are also used for disease modeling, personalized medicine, and understanding the underlying medical conditions related to liver disease, including hepatocellular carcinoma and chronic liver diseases. The regulatory environment for biopharmaceuticals is driving the market growth, with a focus on organ-on-a-chip technology and disease modeling to ensure safety and efficacy.
Market Scope |
|
Report Coverage |
Details |
Page number |
133 |
Base year |
2023 |
Historic period |
2018 - 2022 |
Forecast period |
2024-2028 |
Growth momentum & CAGR |
Accelerate at a CAGR of 20% |
Market growth 2024-2028 |
USD 3.46 billion |
Market structure |
Fragmented |
YoY growth 2023-2024(%) |
16.4 |
Regional analysis |
North America, Europe, APAC, Middle East and Africa, and South America |
Performing market contribution |
North America at 42% |
Key countries |
US, Germany, UK, China, and Japan |
Competitive landscape |
Leading Companies, Market Positioning of Companies, Competitive Strategies, and Industry Risks |
Key companies profiled |
BioIVT LLC, CELLINK AB, CN Bio Innovations Ltd., Corning Inc., Cyfuse Biomedical K.K., Emulate Inc., H. L. Scientific, Hangzhou Jienuofei Biotechnology Co. Ltd., InSphero AG, Kirkstall Ltd., LifeSpan BioSciences Inc., MIMETAS BV, N. C. KANSIL and SONS, Organovo Holdings Inc., Pandorum Technologies Pvt. Ltd., STEMCELL Technologies Inc., Thermo Fisher Scientific Inc., and Western Surgical |
Market dynamics |
Parent market analysis, Market growth inducers and obstacles, Fast-growing and slow-growing segment analysis, COVID-19 impact and recovery analysis and future consumer dynamics, Market condition analysis for forecast period |
Customization purview |
If our report has not included the data that you are looking for, you can reach out to our analysts and get segments customized. |
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1 Executive Summary
2 Market Landscape
3 Market Sizing
4 Historic Market Size
5 Five Forces Analysis
6 Market Segmentation by Type
7 Customer Landscape
8 Geographic Landscape
9 Drivers, Challenges, and Opportunity/Restraints
10 Competitive Landscape
11 Competitive Analysis
12 Appendix
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