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The human liver models market size is forecast to increase by USD 3.46 billion, at a CAGR of 20% between 2023 and 2028.
Explore in-depth regional segment analysis with market size data - historical 2018-2022 and forecasts 2024-2028 - in the full report.
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The market is a dynamic and evolving field, driven by the ongoing research and development in various sectors, including alcoholic liver disease, hepatic stellate cells, tissue engineering approaches, drug metabolism studies, liver cancer models, liver fibrosis models, kupffer cell function, and liver regeneration studies. These areas continue to unfold, with new discoveries and innovations shaping the market landscape. Alcoholic liver disease, for instance, remains a significant focus as researchers explore the intricacies of this condition. Hepatic stellate cells, key players in liver fibrosis, are being studied through various tissue engineering approaches to better understand their role and potential therapeutic targets.
In the realm of drug metabolism, liver models are essential for understanding metabolic pathways and evaluating the activity of cytochrome P450 enzymes and urea synthesis. Liver cancer models and fibrosis models are crucial for disease understanding and drug development. Gene expression profiling and proteomic analysis provide valuable insights into the complex cellular processes involved in these conditions. High content imaging, microsome preparations, and cell signaling pathways are among the tools used to study these models, offering a deeper understanding of liver function and disease progression. Three-dimensional liver models, disease modeling platforms, liver toxicity prediction, and hepatotoxicity testing are also gaining traction.
These advanced techniques enable researchers to better assess liver function, including albumin production, liver cell metabolism, bilirubin metabolism, and liver inflammation. Microfluidic liver devices and human liver slices offer additional advantages, allowing for more precise and realistic studies of liver function and disease. The continuous evolution of liver models is crucial for advancing our understanding of liver biology and developing new therapeutic strategies. These models contribute to the development of novel drugs and treatments, ensuring the ongoing relevance and growth of the market.
The human liver models industry research report provides comprehensive data (region-wise segment analysis), with forecasts and estimates in "USD million" for the period 2024-2028, as well as historical data from 2018-2022 for the following segments.
The liver organoids segment is estimated to witness significant growth during the forecast period.
The liver is a vital organ involved in numerous metabolic processes, including drug metabolism, urea synthesis, bilirubin metabolism, and albumin production. Understanding liver diseases, such as alcoholic liver disease, liver cancer, fibrosis, and cholestasis, requires comprehensive research. Traditional methods like cell culture and animal models have limitations in fully elucidating the complex mechanisms and therapeutic potentials of these diseases. Recent advancements in 3D liver models, such as organoid culture protocols, have emerged as promising alternatives. These models use pluripotent and adult stem cells to form self-organizing structures, enabling individualized liver disease research. Tissue engineering approaches, including 3D liver models, have gained significant attention due to their potential to mimic the liver's complex microenvironment and recapitulate the functions of various cell types, including hepatocytes, hepatic stellate cells, kupffer cells, and endothelial cells.
Liver diseases, including alcoholic liver disease, liver fibrosis, and liver cancer, have a high incidence and are influenced by various factors, including metabolic pathways, cyp450 enzyme activity, and cell signaling pathways. The study of these diseases involves understanding their underlying mechanisms, predicting liver toxicity, and testing hepatotoxicity using hepatocyte function assays. Moreover, liver inflammation plays a crucial role in the development and progression of various liver diseases. Researchers employ high content imaging, proteomic analysis, and gene expression profiling to gain insights into the molecular mechanisms of liver inflammation and its impact on liver cell metabolism. In addition, microfluidic liver devices and liver perfusion systems have been developed to study liver function and metabolism under physiological conditions.
These advanced tools enable researchers to investigate the functions of liver cells, including metabolism, urea synthesis, and bilirubin metabolism, under controlled conditions. In conclusion, the liver research market is witnessing significant growth due to the increasing incidence of liver diseases and the need for more accurate and personalized disease models. The advancements in 3D liver models, organoid culture protocols, and other technologies offer new opportunities for understanding liver diseases and developing effective therapeutic strategies.
The Liver organoids segment was valued at USD 845.10 billion in 2018 and showed a gradual increase during the forecast period.
North America is estimated to contribute 42% to the growth of the global market during the forecast period. Technavio's analysts have elaborately explained the regional trends and drivers that shape the market during the forecast period.
The market is witnessing significant growth due to the increasing research focus on understanding liver functions, particularly in the context of various liver-related diseases such as alcoholic liver disease, liver cancer, and liver fibrosis. Tissue engineering approaches are gaining popularity for creating advanced in vitro models, enabling the study of complex metabolic pathways, including drug metabolism, urea synthesis, and bilirubin metabolism. These models facilitate gene expression profiling, proteomic analysis, and high content imaging, providing valuable insights into cell signaling pathways and liver inflammation. Kupffer cell function and hepatocyte function assays are essential components of these models, allowing for the investigation of hepatotoxicity testing and liver toxicity prediction.
Three-dimensional liver models and microfluidic liver devices are emerging as innovative disease modeling platforms, offering more immersive and harmonious representations of liver cell metabolism. Pharmaceutical companies are investing heavily in these models to better understand metabolic pathways, CYP450 enzyme activity, and liver regeneration studies. In the US, the oncology sector's substantial investments contribute significantly to the North American market's dominance. The presence of major pharmaceutical companies in the region further bolsters its position as a global leader in human liver models research. In the context of cancer, liver cancer models play a crucial role in understanding the disease's progression and developing potential treatments.
For instance, bile duct cancer, which affects an estimated 8,000 people annually in the US, can be studied using these models to explore novel therapeutic approaches. In summary, the market is experiencing substantial growth due to the increasing demand for advanced in vitro models to study various liver-related diseases, including alcoholic liver disease, liver cancer, and liver fibrosis. Tissue engineering approaches, 3D liver models, and microfluidic liver devices are driving innovation in this field, while the oncology sector's investments in the US contribute significantly to the market's dominance.
Our researchers analyzed the data with 2023 as the base year, along with the key drivers, trends, and challenges. A holistic analysis of drivers will help companies refine their marketing strategies to gain a competitive advantage.
The market is witnessing significant growth due to the increasing demand for advanced in vitro methods to study liver function, drug metabolism, and hepatotoxicity. Three-dimensional (3D) liver organoid cultures have emerged as a promising tool for modeling liver physiology and disease. These models allow for the formation of complex liver structures, including hepatic spheroids and liver-on-a-chip systems, which mimic the liver's microenvironment and enable more accurate predictions of drug metabolism and hepatotoxicity. Liver cell lines, such as HepG2 and Huh7, are widely used for drug screening and disease modeling. However, these models have limitations in fully recapitulating liver function and complexity. To address this, researchers are exploring the use of induced pluripotent stem cell (iPSC)-derived hepatocytes and primary human hepatocytes for more accurate models. Advanced technologies, such as 3D bioprinting and high-content imaging analysis, are also being employed to create more complex and functional human liver models. These models enable the quantification of CYP450 enzyme activity, albumin production, and the evaluation of cell signaling pathways in liver disease. Furthermore, microfluidic liver chips and liver regeneration using stem cells offer potential solutions for in vitro assessment of liver fibrosis and alcoholic and non-alcoholic fatty liver disease. The development of personalized medicine approaches using human liver models is a key area of focus in the market. These models enable the prediction of drug-induced liver injury and the optimization of drug dosing and delivery strategies based on individual patient characteristics. Overall, the market is expected to continue growing as researchers and pharmaceutical companies seek to improve the accuracy and relevance of in vitro liver models for drug discovery and development.
The human liver models market forecasting report includes the adoption lifecycle of the market, covering from the innovator's stage to the laggard's stage. It focuses on adoption rates in different regions based on penetration. Furthermore, the human liver models market report also includes key purchase criteria and drivers of price sensitivity to help companies evaluate and develop their market growth analysis strategies.
Customer Landscape
Companies are implementing various strategies, such as strategic alliances, human liver models market forecast, partnerships, mergers and acquisitions, geographical expansion, and product/service launches, to enhance their presence in the industry.
BioIVT LLC - The company specializes in providing advanced human liver models for research applications, with a focus on the Human Liver S9 model.
The industry research and growth report includes detailed anlyses of the competitive landscape of the market and information about key companies, including:
Qualitative and quantitative analysis of companies has been conducted to help clients understand the wider business environment as well as the strengths and weaknesses of key industry players. Data is qualitatively analyzed to categorize companies as pure play, category-focused, industry-focused, and diversified; it is quantitatively analyzed to categorize companies as dominant, leading, strong, tentative, and weak.
Dive into Technavio's robust research methodology, blending expert interviews, extensive data synthesis, and validated models for unparalleled Human Liver Models Market insights. See full methodology.
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Market Scope |
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Report Coverage |
Details |
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Page number |
133 |
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Base year |
2023 |
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Historic period |
2018-2022 |
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Forecast period |
2024-2028 |
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Growth momentum & CAGR |
Accelerate at a CAGR of 20% |
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Market growth 2024-2028 |
USD 3455.5 million |
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Market structure |
Fragmented |
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YoY growth 2023-2024(%) |
16.4 |
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Key countries |
US, Germany, UK, China, and Japan |
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Competitive landscape |
Leading Companies, Market Positioning of Companies, Competitive Strategies, and Industry Risks |
We can help! Our analysts can customize this human liver models market research report to meet your requirements.
1 Executive Summary
2 Market Landscape
3 Market Sizing
4 Historic Market Size
5 Five Forces Analysis
6 Market Segmentation by Type
7 Customer Landscape
8 Geographic Landscape
9 Drivers, Challenges, and Opportunity/Restraints
10 Competitive Landscape
11 Competitive Analysis
12 Appendix
Research Framework
Technavio presents a detailed picture of the market by way of study, synthesis, and summation of data from multiple sources. The analysts have presented the various facets of the market with a particular focus on identifying the key industry influencers. The data thus presented is comprehensive, reliable, and the result of extensive research, both primary and secondary.
INFORMATION SOURCES
Primary sources
Secondary sources
DATA ANALYSIS
Data Synthesis
Data Validation
REPORT WRITING
Qualitative
Quantitative
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