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The global electroporation and electrofusion market size is estimated to grow by USD 238.95 million, at a CAGR of 7.27% between 2023 and 2028.
Electroporation and electrofusion play vital roles in biologics development, enabling gene delivery and hybrid cell creation for therapeutic molecule production. Electroporation aids gene therapy by efficiently delivering genes into cells, while electrofusion is crucial for generating hybrid cells, particularly for monoclonal antibody production in biologics. Globally, numerous projects focus on disease treatment, with 173 in DNA and RNA therapeutics, 731 in cell and gene therapies, and 188 in conjugated monoclonal antibodies. The surge in projects drives demand for electroporation and electrofusion consumables, crucial for wet lab procedures analyzing biologicals used in therapeutic production. Monoclonal antibodies, key biologics, find applications in diverse medical fields, fueling demand for new production technologies. Major manufacturers, like Lonza and Thermo Fisher Scientific, invest in large-scale facilities equipped with electroporation instruments to meet the rising demand for monoclonal antibodies, driving the growth of the global electroporation and electrofusion market during the forecast period.
Technavio has segmented the market into Product, End-user, and Geography
It also includes an in-depth analysis of drivers, trends, and challenges. Our report examines historical data from 2018 - 2022, besides analyzing the current market scenario.
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The market share growth by the consumables segment will be significant during the forecast period. Consumables include kits that contain resuspension and electrolytic buffers, electroporation tubes, reaction tips, cuvettes, etc. The demand for consumables, especially from academic institutes and pharmaceutical companies involved in cell-based research, is increasing.
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The consumables segment was the largest and was valued at USD 244.94 million in 2018. Further, companies provide clinical-grade products for sample preparation, cell separation, flow cytometry, and cell culture applications. This includes reagents used in electrofusion and electroporation procedures. Some of its products, such as CU500 Cuvette Chamber, CU600 Cuvette Holder, and EC-002 Cuvettes, are known to achieve high transfection/electroporation efficiency and high viability. Most vendors in the market also offer reagents and kits for various cell-based experiments, including electroporation and electrofusion. Electroporation and electrofusion consumables are widely used in various cell-based procedures as they are precise and fast in action. They are cost-effective as they can be reused. These products are in high demand as they come in limited quantities and must be purchased frequently. Thus, the consumables segment is expected to grow significantly and will be the fastest-growing segment in the global electroporation and electrofusion market during the forecast period.
Systems used in electroporation and electrofusion procedures primarily include electroporators and cell fusion units. The major factor driving this segment is the continuous product innovations introduced by the existing players. The increasing use of these advanced products in various cell-based research experiments drives the growth of the segment. The fusion efficiency achieved using the ECFG21 for hybridoma production is higher than polyethylene glycol. MaxCyte Inc. offers ExPERT technology platform. This platform is integrated into the family of instruments the ATx, STx, and GTx, which represents the next generation of the industry's leading, clinically validated Flow Electroporation technology for complex cellular engineering. The advanced features of these systems enable streamlined electroporation procedures and increased processing efficiency. The high cost of these products prevents repeat purchases. Hence, the growth momentum of this segment is slow. However, with constant innovation in the instruments segment, the demand for these products will be high among pharmaceutical companies and CROs. These factors are expected to positively impact the growth of the systems segment of the global electroporation and electrofusion market during the forecast period.
Academic and government research laboratories include end-users, such as universities, government-owned research institutes, and government-owned testing laboratories, which are involved in drug, biological, and vaccine research. These institutes are mainly funded by government bodies that allow the adoption of advanced electroporation and electrofusion instruments. These laboratories conduct advanced research activities in fields such as proteomics, medicine, and metabolomics. This has increased the demand for advanced transfection products from the education sector, such as electroporation instruments. Further, the increasing ability to treat diseases through regenerative medicine, without the process of painful surgery, has resulted in an increased demand for regenerative medicines, which, in turn, depend on transfection products such as electroporation and electrofusion instruments. Hence, the increasing application of electroporation and electrofusion devices in academic and research institutes for various downstream processes will increase the demand for these products, thus driving the growth of the academic and government research institutes segment of the global electroporation and electrofusion market during the forecast period.
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North America is estimated to contribute 35% to the growth of the global market during the forecast period. Technavio’s analysts have elaborately explained the regional market trends and analysis and drivers will shape the market during the market growth and forecasting period. North America was the largest contributor to the global electroporation and electrofusion market in 2023, with the US leading the regional market in terms of revenue. Recent advances in biotechnology and pharmaceutical research, focus on drug and vaccine discovery, the increasing focus on developing transgenic crops and animals, and the presence of many vendors in the US offering a wide range of products are supporting the market growth and trends of the electroporation and electrofusion market. Vendors are increasingly investing in new manufacturing facilities that develop the required bioprocessing units and other necessary equipment for processes such as cell line development and cell culture.
In addition, the process for the development of cell lines is initiated by transfecting selected host cells, such as CHO or HEK 293 cells, with desired plasmids using electroporation instruments. After transfection, high-expressing clones are screened and quantified. Therefore, the development of cell lines will increase the adoption of electroporation and electrofusion products, thus driving market growth during the market forecast period.
Companies are implementing various strategies, such as strategic alliances, partnerships, mergers and acquisitions, geographical expansion, and product/service launches, to enhance their presence in the market. The market analysis and report also includes detailed analyses of the competitive landscape of the market and information about 15 market companies, including:
AngioDynamics Inc. - The company offers electroporation and electrofusion such as Nanoknife irreversible electroporation that allow the device to be used in all segments of an organ to optimize treatment delivery.
Qualitative and quantitative analysis of companies has been conducted to help clients understand the wider business environment as well as the strengths and weaknesses of key market players. Data is qualitatively analyzed to categorize companies as pure play, category-focused, industry-focused, and diversified; it is quantitatively analyzed to categorize companies as dominant, leading, strong, tentative, and weak.
There are multiple factors influencing market growth analysis. Our researchers analyzed the data with 2023 as the base year, along with the key drivers, trends, and challenges.
The growing incidence and prevalence of cancer are notably driving the market growth. Cancer is among the top five causes of death across all age groups globally. However, the low- and middle-income countries are the most affected. Lung cancer caused by tobacco is one of the most common types of cancer in low- and middle-income countries. Liver cancer, which is caused by the hepatitis B virus, and cervical cancer, which is caused by the human papillomavirus, can be prevented using vaccines. These vaccines are also commonly available. Electroporation and electrofusion are some of the advanced molecular biology techniques used in cancer treatment.
Moreover, electroporation products are used to damage cell membranes by electroporation to the extent that cancerous cells are destroyed in the process. This leads to leakage of intracellular contents from the cellular membrane. Thus, cancerous cells die by apoptosis, which is unique to this ablation technique in comparison to other ablation systems that induce necrosis either by radiation or heat. This advantage provided by electroporation is increasing its adoption, which is expected to drive the growth of the market during the forecast period.
Increasing demand for gene therapy is an emerging trend shaping the market growth. Gene therapy emerges as a promising approach for treating a variety of genetic disorders, cancers, and other diseases at the molecular level. Electroporation and electrofusion technologies play a pivotal role in gene therapy, facilitating the delivery of therapeutic genes into target cells. The rising prevalence of genetic diseases and the quest for more effective and personalized treatment options have spurred the exploration of gene-based interventions. Electroporation, with its ability to enhance cellular uptake of genetic material, has become a key method for introducing therapeutic genes into cells.
Moreover, as gene therapy continues to advance and gain traction in the medical community, the global electroporation and electrofusion market is poised for sustained growth, reflecting the indispensable role these technologies play in the development and application of cutting-edge gene-based therapies. Therefore, the increasing demand for gene therapy will drive the growth of the global electroporation and electrofusion market during the forecast period.
Disruptions associated with the efficiency of electroporation and electrofusion devices are a significant challenge hindering market growth. Transfection, with the help of electroporation devices, is being increasingly used to neutralize or eliminate the need to introduce negatively charged molecules into cells with a negatively charged membrane. Further, the cells used during the process need to be grown in a medium appropriate for the cell line and supplemented with growth factors (serum) as needed for viability. Any contaminated cell should be discarded and reseeded from a frozen, uncontaminated stock. A compromised cell can harm cell growth. The cell also needs to be transfected at 40%-80% confluency, as too many cells can result in contact inhibition.
Similarly, the number of passages should be limited as their characteristics can change over time, leading to the lack of cell response to transfection conditions, thereby resulting in poor expression. With the presence of several factors affecting transfection results, utmost care must be taken to get accurate results. An inaccurate result can lead to the wastage of consumables and decrease the demand for the products, thus hindering the growth of the global electroporation and electrofusion market during the forecast period.
The market report includes the adoption lifecycle of the market, covering from the innovator’s stage to the laggard’s stage. It focuses on adoption rates in different regions based on penetration. Furthermore, the report also includes key purchase criteria and drivers of price sensitivity to help companies evaluate and develop their market research and growth strategies.
Global Electroporation and Electrofusion Market Customer Landscape
The electroporation and electrofusion market report forecasts market growth by revenue at global, regional & country levels and provides an analysis of the latest trends and growth opportunities from 2018 to 2028.
Electroporation and Electrofusion Market Scope |
|
Report Coverage |
Details |
Page number |
160 |
Base year |
2023 |
Historic period |
2018-2022 |
Market forecasting period |
2024-2028 |
Growth momentum & CAGR |
Accelerate at a CAGR of 7.27% |
Market Growth 2024-2028 |
USD 238.95 million |
Market structure |
Fragmented |
YoY growth 2023-2024(%) |
6.85 |
Regional analysis |
North America, Europe, Asia, and Rest of World (ROW) |
Performing market contribution |
North America at 35% |
Key countries |
US, Germany, UK, China, and Japan |
Competitive landscape |
Leading Companies, Market Positioning of Companies, Competitive Strategies, and Industry Risks |
Key companies profiled |
AngioDynamics Inc., BEATIFIC Corp., BEX Co. Ltd., Bio Rad Laboratories Inc., Biogenuix Medsystems Pvt. Ltd., Celetrix LLC, Eppendorf SE, Gamma Biosciences, Gel Co. Inc, Harvard Bioscience Inc., Lonza Group Ltd., MaxCyte Inc., Merck KGaA, Miltenyi Biotec B.V. and Co. KG, MoBiTec GmbH, Nepa Gene Co. Ltd., Richmond Scientific Ltd., Thermo Fisher Scientific Inc., and Westburg BV |
Market dynamics |
Parent market analysis, Market growth inducers and obstacles, Fast-growing and slow-growing segment analysis, COVID-19 impact and recovery analysis and future consumer dynamics, Market condition analysis for the forecast period |
Customization purview |
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1 Executive Summary
2 Market Landscape
3 Market Sizing
4 Historic Market Size
5 Five Forces Analysis
6 Market Segmentation by Product
7 Market Segmentation by End-user
8 Customer Landscape
9 Geographic Landscape
10 Drivers, Challenges, and Trends
11 Vendor Landscape
12 Vendor Analysis
13 Appendix
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